SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 21, 2001 ARQULE, INC. (Exact Name of Issuer as Specified in Charter) Delaware 000-21429 04-3221586 -------------- ------------ ---------------- (State or other jurisdiction (Commission File Number) (I.R.S. Employer of incorporation) Identification No.) 19 Presidential Way Woburn, MA ------------------- (Address of principal executive offices) 01801 ----- (Zip code) (781) 994-0300 -------------- (Registrant's telephone number, including area code) Item 5. Other Events On December 20, 2001, ArQule, Inc. entered into a significant expansion and extension of its strategic alliance with Pfizer, Inc, originally established in 1999. A press release describing the terms of the extension is included as an exhibit to this report and is incorporated by reference herein. Item 7. Financial Statements, Pro Forma Financial Information and Exhibits (c) Exhibits 99.1 Text of Press Release, dated December 21, 2001. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. ARQULE, INC. (Registrant) /s/ Stephen A. Hill ----------------------------------- Stephen A. Hill President and Chief Executive Officer Date: December 21, 2001