UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                    ----------------------------------------

                                    FORM 8-K/A

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

        Date of report (Date of earliest event reported): April 20, 2006
                                                          --------------

                               CYTOGEN CORPORATION
                ------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)

          Delaware                       000-14879                22-2322400
----------------------------     ------------------------    -------------------
(State or Other Jurisdiction     (Commission File Number)     (I.R.S. Employer
      of Incorporation)                                      Identification No.)

650 College Road East, CN 5308, Suite 3100, Princeton, NJ            08540
---------------------------------------------------------     ------------------
        (Address of Principal Executive Offices)                  (Zip Code)

       Registrant's telephone number, including area code: (609) 750-8200
                                                           --------------


--------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)


     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     |_|  Written communications  pursuant to Rule 425 under the  Securities Act
(17 CFR 230.425)

     |_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_|  Pre-commencement  communications  pursuant to Rule 14d-2(b)  under the
Exchange Act (17 CFR 240.14d-2(b))

     |_|  Pre-commencement  communications  pursuant to Rule 13e-4(c)  under the
Exchange Act (17 CFR 240.13e-4(c))





ITEM 2.01    COMPLETION OF ACQUISITION OR DISPOSITION OF ASSETS

     This Form 8-K/A  amends  the Form 8-K and the Form  8-K/A  filed by Cytogen
Corporation  (the  "Company")  on April 26, 2006 with respect to the sale by the
Company to Progenics  Pharmaceuticals,  Inc.  ("Progenics") of the Company's 50%
ownership  interest in PSMA Development  Company LLC (the "Joint  Venture").  On
April  20,  2006,  the  Company  entered  into a  Membership  Interest  Purchase
Agreement  with  Progenics  providing for the sale to Progenics of the Company's
50% ownership  interest in the Joint Venture.  In addition,  the Company entered
into an Amended and Restated  PSMA/PSMP License Agreement with Progenics and the
Joint Venture  pursuant to which the Company  licensed the Joint Venture certain
rights in PSMA technology.  Under the terms of such agreements, the Company sold
its 50%  interest  in the Joint  Venture  for an upfront  cash  payment of $13.2
million,  potential future milestone payments totaling up to $52 million payable
upon regulatory  approval and  commercialization  of the Joint Venture products,
and an undisclosed royalty on future product sales of the Joint Venture.

     The following selected unaudited pro forma balance sheet information of the
Company  reflects the  disposition of the Joint Venture as if it had occurred on
December 31, 2005. The accompanying  unaudited pro forma statement of operations
information for the year December 31, 2005 reflects the disposition of the Joint
Venture  as if the  sale  had  occurred  on  January  1,  2005.  The  pro  forma
adjustments  are based on the  operations of the Joint Venture during the period
presented and the impact from the sale of the Joint Venture.  Consequently,  the
pro forma financial information  presented is not necessarily  indicative of the
results that would have been reported had the transactions  actually occurred on
the date  specified.  The pro forma  adjustments  do not  include  any gain  the
Company may record in connection with this transaction.

     The pro forma  adjustments  for the years ended  December 31, 2005 from the
sale of the  Company's  50%  ownership  interest in the Joint Venture would have
reduced  license  and  contract  revenue  by  $185,000,  equity in loss of Joint
Venture by $3.2 million,  and operating loss by $3.0 million, or $0.18 per basic
and diluted  share.  In addition,  the pro forma  adjustments as of December 31,
2005 from the sale of the Company's 50% ownership  interest in the Joint Venture
would have increased cash and cash  equivalents by $13.2 million,  reduced other
assets by $379,000 and reduced accumulated deficit by $12.8 million.

     The  following   selected  unaudited  pro  forma  condensed  balance  sheet
information  and statement of  operations  information  reflects the  historical
financial information, adjusted for the pro forma adjustments discussed above:





SELECTED UNAUDITED PRO FORMA STATEMENT OF OPERATIONS DATA:

                                                     FOR YEAR ENDED
                                                   DECEMBER 31, 2005
                                   (ALL AMOUNTS IN THOUSANDS, EXCEPT SHARE DATA)
                                   ---------------------------------------------


License and contract revenue                      $         4
Equity in loss of joint venture                   $        --
Operating loss                                    $   (25,819)
Basic and diluted net loss per sha                $     (1.36)



SELECTED UNAUDITED PRO FORMA BALANCE SHEET DATA:

                                                       AS OF
                                                 DECEMBER 31, 2005
                                             (ALL AMOUNTS IN THOUSANDS)
                                             --------------------------

Cash and cash equivalents                         $    43,537
Other assets                                      $       276
Accumulated deficit                               $  (399,746)





                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                        CYTOGEN CORPORATION



                                        By: /s/ Michael D. Becker
                                           -------------------------------------
                                           Michael D. Becker
                                           President and Chief Executive Officer

Dated:   April 28, 2006