Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
  2. Issuer Name and Ticker or Trading Symbol
COMPLETE GENOMICS INC [GNOM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O ESSEX WOODLANDS HEALTH VENTURES, 21 WATERWAY AVENUE, SUITE 225
3. Date of Earliest Transaction (Month/Day/Year)
11/16/2010
(Street)

THE WOODLANDS, TX 77380
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $0.001 11/16/2010   C   2,061,134 A (1) 2,061,134 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   C   1,159,218 A (1) 3,220,352 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   P(7)   546,268 A $ 9 3,766,620 I See Footnote (2)
Common Stock, par value $0.001 11/16/2010   C   148,608 A (1) 148,608 I See Footnote (3)
Common Stock, par value $0.001 11/16/2010   C   83,580 A (1) 232,188 I See Footnote (3)
Common Stock, par value $0.001 11/16/2010   P(8)   39,386 A $ 9 271,574 I See Footnote (3)
Common Stock, par value $0.001 11/16/2010   C   64,612 A (1) 64,612 I See Footnote (4)
Common Stock, par value $0.001 11/16/2010   C   36,339 A (1) 100,951 I See Footnote (4)
Common Stock, par value $0.001 11/16/2010   P(9)   17,124 A $ 9 118,075 I See Footnote (4)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series D Preferred Stock (1) (1) 11/16/2010   C     2,061,134   (5)   (6) Common Stock 2,061,134 (1) 0 I See Footnote (2)
Series D Preferred Stock (1) (1) 11/16/2010   C     148,608   (5)   (6) Common Stock 148,608 (1) 0 I See Footnote (3)
Series D Preferred Stock (1) (1) 11/16/2010   C     64,612   (5)   (6) Common Stock 64,612 (1) 0 I See Footnote (4)
Series E Preferred Stock (1) (1) 11/16/2010   C     1,159,218   (5)   (6) Common Stock 1,159,218 (1) 0 I See Footnote (2)
Series E Preferred Stock (1) (1) 01/16/2010   C     83,580   (5)   (6) Common Stock 83,580 (1) 0 I See Footnote (3)
Series E Preferred Stock (1) (1) 01/16/2010   C     36,339   (5)   (6) Common Stock 36,339 (1) 0 I See Footnote (4)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
C/O ESSEX WOODLANDS HEALTH VENTURES
21 WATERWAY AVENUE, SUITE 225
THE WOODLANDS, TX 77380
    X    
ESSEX WOODLANDS HEALTH VENTURES FUND VIII-A LP
C/O ESSEX WOODLANDS HEALTH VENTURES
21 WATERWAY AVENUE, SUITE 225
THE WOODLANDS, TX 77380
    X    
ESSEX WOODLANDS HEALTH VENTURES FUND VIII-B LP
C/O ESSEX WOODLANDS HEALTH VENTURES
21 WATERWAY AVENUE, SUITE 225
THE WOODLANDS, TX 77380
    X    

Signatures

 /s/ Jeff Himawan, Manager, Essex Woodlands Health Ventures Fund VIII, L.P.   11/16/2010
**Signature of Reporting Person Date

 /s/ Jeff Himawan, Manager, Essex Woodlands Health Ventures Fund VIII-A, L.P.   11/16/2010
**Signature of Reporting Person Date

 /s/ Jeff Himawan, Manager, Essex Woodlands Health Ventures Fund VIII-B, L.P.   11/16/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each share of Series D and Series E Preferred Stock will automatically convert on a 1 for 1 basis into common stock upon the closing of the Issuer's initial public offering.
(2) The shares are owned by Essex Woodlands Health Ventures Fund VIII, L.P. ("Essex Woodlands Ventures Fund"). Essex Woodlands Health Ventures VIII, L.P. ("Essex Ventures L.P.") serves as the general partner of Essex Woodlands Ventures Fund and Essex Woodlands Health Ventures VIII, LLC ("Essex Ventures LLC") serves as the general partner of Essex Ventures L.P. James Currie, Ron Eastman, Jeff Himawan, Ph.D., Guido Neels, Martin Sutter, Immanuel Thangaraj, Petri Vainio, M.D., Ph.D. and Steve Wiggins are managing directors of Essex Ventures LLC and are deemed to have shared voting and investment power over the shares held by Essex Woodlands Ventures Fund. Each of the managing directors disclaims beneficial ownership of the shares held by Essex Woodlands Ventures Fund except to the extent of any pecuniary interest therein.
(3) The shares are owned by Essex Woodlands Health Ventures Fund VIII A, L.P. ("Essex Woodlands Fund A"). Essex Ventures L.P. serves as the general partner of Essex Woodlands Fund A and Essex Ventures LLC serves as the general partner of Essex Ventures L.P. James Currie, Ron Eastman, Jeff Himawan, Ph.D., Guido Neels, Martin Sutter, Immanuel Thangaraj, Petri Yaino, M.D., Ph.D. and Steve Wiggans are managing directors of Essex Ventures LLC and are deemed to have shared voting and investment power over the shares held by Essex Woodlands Fund A. Each of the managing directors disclaims beneficial ownership of the shares held by Essex Woodlands Fund A except to the extent of any pecuniary interest therein.
(4) The shares are owned by Essex Woodlands Health Ventures Fund VIII B, L.P. ("Essex Woodlands Fund B"). Essex Ventures L.P. serves as the general partner of Essex Woodlands Fund B and Essex Ventures LLC serves as the general partner of Essex Ventures L.P. James Currie, Ron Eastman, Jeff Himawan, Ph.D., Guido Neels, Martin Sutter, Immanuel Thangaraj, Petri Yaino, M.D., Ph.D. and Steve Wiggans are managing directors of Essex Ventures LLC and are deemed to have shared voting and investment power over the shares held by Essex Woodlands Fund B. Each of the managing directors disclaims beneficial ownership of the shares held by Essex Woodlands Fund B except to the extent of any pecuniary interest therein.
(5) The securities are immediately convertible.
(6) The expiration date is not relevant to the conversion of these securities.
(7) Essex Woodlands Ventures Fund purchased an additional 546,268 shares of Issuer's common stock in connection with the initial public offering at the offering price of $9.00 per share.
(8) Essex Woodlands Fund A purchased an additional 39,386 shares of Issuer's common stock in connection with the initial public offering at the offering price of $9.00 per share.
(9) Essex Woodlands Fund B purchased an additional 17,124 shares of Issuer's common stock in connection with the initial public offering at the offering price of $9.00 per share.

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