------------------------------
                                                           OMB APPROVAL
                                                  OMB Number     3235-0145
                                                  Expires:   December 31, 2005
                                                  Estimated average burden
                                                  hours per response . . . 11
                                                  ------------------------------


                                                
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                          

      
                              INITIAL SCHEDULE 13G
                                                
                                                
                                                
                                                
                                                

                    Under the Securities Exchange Act of 1934


                           Caliper Life Sciences, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    896095106
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2004
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

           [ X ]  Rule 13d-1(b)

           [   ]  Rule 13d-1(c)

           [   ]  Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).






                                PAGE 1 OF 9 PAGES






                                                                               

-----------------------------------------                                        --------------------------------------
CUSIP No.   896095106                                      13G                   Page  2  of  9  Pages
-----------------------------------------                                        --------------------------------------

---------- -------------------------------------------------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only).

           Manulife Financial Corporation
           I.R.S. No.

---------- -------------------------------------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|
                                                                                  (b)  |_|
           N/A

---------- -------------------------------------------------------------------------------------------------------------
    3      SEC USE ONLY

---------- -------------------------------------------------------------------------------------------------------------
    4      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

---------- -------------------------------------------------------------------------------------------------------------
                       5     SOLE VOTING POWER

                             1,832,812:  605 directly and 1,832,207 through its indirect, wholly-owned subsidiary,
                             John Hancock Advisers, LLC
    Number of
      Shares
   Beneficially
     Owned by
       Each
    Reporting
      Person
       With
                    -------- -------------------------------------------------------------------------------------------
                       6     SHARED VOTING POWER

                             -0-

                    -------- -------------------------------------------------------------------------------------------
                       7     SOLE DISPOSITIVE POWER

                             1,832,812:  605 directly and 1,832,207 through its indirect, wholly-owned subsidiary,
                             John Hancock Advisers, LLC

                    -------- -------------------------------------------------------------------------------------------
                       8     SHARED DISPOSITIVE POWER

                             -0-
                    
---------- -------------------------------------------------------------------------------------------------------------
    9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,832,812:  605 directly and 1,832,207 through its indirect, wholly-owned subsidiary, John Hancock
           Advisers, LLC


---------- -------------------------------------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A

---------- -------------------------------------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           6.19%:  .00002% directly and 6.19% through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC


---------- -------------------------------------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           HC

---------- -------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                PAGE 2 OF 9 PAGES







                                                                            
-----------------------------------------                                        --------------------------------------
CUSIP No.   896095106                                      13G                   Page  3  of  9  Pages
-----------------------------------------                                        --------------------------------------

---------- -------------------------------------------------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only).

           John Hancock Financial Services, Inc.
           I.R.S. No. 04-3483032

---------- -------------------------------------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|
                                                                                  (b)  |_|
           N/A

---------- -------------------------------------------------------------------------------------------------------------
    3      SEC USE ONLY

---------- -------------------------------------------------------------------------------------------------------------
    4      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

---------- -------------------------------------------------------------------------------------------------------------
                       5     SOLE VOTING POWER

                             -0-

    Number of
      Shares
   Beneficially
     Owned by
       Each
    Reporting
      Person
       With
                    -------- -------------------------------------------------------------------------------------------
                       6     SHARED VOTING POWER

                             -0-

                    -------- -------------------------------------------------------------------------------------------
                       7     SOLE DISPOSITIVE POWER

                             -0-

                    -------- -------------------------------------------------------------------------------------------
                       8     SHARED DISPOSITIVE POWER

                             -0-
                    
---------- -------------------------------------------------------------------------------------------------------------
    9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           None, except through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC


---------- -------------------------------------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A

---------- -------------------------------------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           See line 9, above.

---------- -------------------------------------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           HC

---------- -------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                PAGE 3 OF 9 PAGES







                                                                            
-----------------------------------------                                        --------------------------------------
CUSIP No.   896095106                                      13G                   Page  7  of  9  Pages
-----------------------------------------                                        --------------------------------------

---------- -------------------------------------------------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only).

           John Hancock Advisers, LLC
           I.R.S. No. 04-2441573

---------- -------------------------------------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|
                                                                                  (b)  |_|
           N/A

---------- -------------------------------------------------------------------------------------------------------------
    3      SEC USE ONLY

---------- -------------------------------------------------------------------------------------------------------------
    4      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

---------- -------------------------------------------------------------------------------------------------------------
                       5     SOLE VOTING POWER

                             1,832,207

    Number of
      Shares
   Beneficially
     Owned by
       Each
    Reporting
      Person
       With
                    -------- -------------------------------------------------------------------------------------------
                       6     SHARED VOTING POWER

                             -0-

                    -------- -------------------------------------------------------------------------------------------
                       7     SOLE DISPOSITIVE POWER

                             1,832,207

                    -------- -------------------------------------------------------------------------------------------
                       8     SHARED DISPOSITIVE POWER

                             -0-
                    
---------- -------------------------------------------------------------------------------------------------------------
    9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,832,207

---------- -------------------------------------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A

---------- -------------------------------------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           6.1%

---------- -------------------------------------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IA

---------- -------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                PAGE 4 OF 9 PAGES






       

         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule,  including all  exhibits.  See Sec.  240.13d-7 for other
parties for whom copies are to be sent.

     Attention:  Intentional  misstatements  or  omissions  of  fact  constitute
     Federal criminal violations (See 18 U.S.C. 1001)

         Item 1(a)    Name of Issuer:
                      --------------
                      Caliper Life Sciences Inc

         Item 1(b)    Address of Issuer's Principal Executive Offices:
                      -----------------------------------------------
                      68 Elm Street
                      Hopkinton, Massachusetts 01748

         Item 2(a)    Name of Person Filing:
                      ---------------------
                      This filing is made on behalf of Manulife Financial
                      Corporation ("MFC"), and MFC's indirect, wholly-owned
                      subsidiary, John Hancock Financial Services, Inc.
                      ("JHFS"), JHFS's indirect, wholly-owned subsidiary, John
                      Hancock Advisers, LLC ("JHA").

         Item 2(b)    Address of the Principal Offices:
                      --------------------------------
                      The principal business offices of MFC are located at 200
                      Bloor Street, East, Toronto, Ontario, Canada, M4W 1E5. The
                      principal business offices of JHFS are located at John
                      Hancock Place, P.O. Box 111, Boston, MA 02117. The
                      principal business offices of JHA are located at 101
                      Huntington Avenue, Boston, Massachusetts 02199.

         Item 2(c)    Citizenship:
                      -----------
                      MFC is organized and exists under the laws of Canada.
                      JHFS and JHA were organized and exist under the laws of
                      the State of Delaware.

         Item 2(d)    Title of Class of Securities:
                      ----------------------------
                      Common Stock

         Item 2(e)    CUSIP Number:
                      ------------
                      896095106

         Item 3       If the Statement is being filed pursuant to Rule
                      ------------------------------------------------
                      13d-1(b), or 13d-2(b), check whether the person filing is a:
                      -----------------------------------------------------------

                      MFC:          (g) (X) Parent Holding Company, in accordance
                                            with ss.240.13d-1(b)(ii)(G).

                      JHFS:         (g) (X) Parent Holding Company, in accordance
                                            with ss.240.13d-1(b)(ii)(G).

                      JHLICO:       (c) (X) Insurance Company as defined in  
                                            ss.3(a)(19) of the Act.

                                    (e) (X) Investment Adviser registered
                                            under ss.203 of the Investment
                                            Advisers Act of 1940.


                                PAGE 5 OF 9 PAGES




                                    (g) (X) Parent Holding Company, in
                                            accordance with ss.240.13d-1(b)(ii)(G).

                      JHS:          (g) (X) Parent Holding Company, in accordance 
                                            with ss.240.13d-1(b)(ii)(G).

                      TBFG:         (g) (X) Parent Holding Company, in accordance
                                            with ss.240.13d-1(b)(ii)(G).

                      JHA:          (e) (X) Investment Adviser registered under ss.203
                                            of the Investment Advisers Act of 1940.

         Item 4       Ownership:
                      ---------

                      (a)          Amount Beneficially Owned:
                                   -------------------------
                                   MFC has direct beneficial ownership of 605 
                                   shares of Common Stock. JHA has direct beneficial
                                   ownership of 1,832,207 shares of Common Stock.
                                   Through their parent-subsidiary relationship to 
                                   JHA, MFC, JHFS have indirect, beneficial
                                   ownership of these shares held by JHA.

                      (b)          Percent of Class:  MFC: 00002% 
                                   ----------------   JHA: 6.1%

                      (c)          Number of shares as to which the person has:
                                   -------------------------------------------

                             (i)   sole power to vote or to direct the vote:
                                   JHA has sole power to vote or to direct the
                                   vote of 1,832,207 shares of Common Stock
                                   under the Advisory Agreements as follows:

                                                                                        Number    Date of Advisory
                         Fund Name                                                     of Shares  Agreement
                         ---------                                                     ---------  ---------
                         Verizon Savings Trust Small Cap Growth                         209,500   December 21, 2001
                         John Hancock Biotechnology Fund                                60,000    March 01, 2001
                         John Hancock Small Cap Growth Fund                            1,562,707  December 02, 1996

                                   In addition, MFC has sole power to vote or
                                   to direct the vote of 605 shares of Common
                                   Stock.

                             (ii)  shared power to vote or to direct the vote: -0-

                             (iii) sole power to dispose or to direct the disposition of:
                                   JHA has sole power to dispose or to direct
                                   the disposition of 1,832,207 shares of
                                   Common Stock under the Advisory Agreement
                                   noted in Item 4(c)(i) above. In addition,
                                   MFC has sole power to dispose or to direct
                                   the disposition of 605 shares of Common
                                   Stock.

                             (iv)  shared power to dispose or to direct the disposition of: -0-

         Item 5       Ownership of Five Percent or Less of a Class:
                      --------------------------------------------
                      Not applicable.

         Item 6       Ownership of More than Five Percent on Behalf of Another Person:
                      ---------------------------------------------------------------
                      See Item 4.



                                PAGE 6 OF 9 PAGES





         Item 7       Identification and Classification of the Subsidiary which Acquired
                      ------------------------------------------------------------------
                      the Security Being Reported on by the Parent Holding Company:
                      ------------------------------------------------------------                    
                      See Items 3 and 4 above.

         Item 8       Identification and Classification of Members of the Group:
                      ---------------------------------------------------------
                      Not applicable.

         Item 9       Notice of Dissolution of a Group:
                      --------------------------------
                      Not applicable.

         Item 10      Certification:
                      -------------
                      By signing below the undersigned certifies that, to the
                      best of its knowledge and belief, the securities referred
                      to above were acquired and are held in the ordinary course
                      of business and were not acquired and are not held for the
                      purpose of or with the effect of changing or influencing
                      the control of the issuer of the securities and were not
                      acquired and are not held in connection with or as a
                      participant in any transaction having that purpose or
                      effect.



                                PAGE 7 OF 9 PAGES




                                    SIGNATURE

         After reasonable inquiry and to the best of its knowledge and belief,
each of the undersigned certifies that the information set forth in this
statement is true, complete and correct.

                                                     Manulife Financial Corporation


                                                     By:      /s/Christer V. Ahlvik
                                                              ------------------------------------------------------
                                                              Name:   Christer V. Ahlvik
Dated:  February 3, 2005                                      Title:  Vice President and Corporate Secretary

                                                     John Hancock Financial Services, Inc.


                                                     By:      /s/Emanuel Alves
                                                              ------------------------------------------------------
                                                              Name:  Emanuel Alves
Dated:  February 3, 2005                                      Title: Vice President and Corporate Secretary

                                                     John Hancock Advisers, LLC


                                                     By:      /s/Susan S. Newton
                                                              ------------------------------------------------------
                                                              Name:    Susan S. Newton
Dated:  February 3, 2005                                      Title:   Senior Vice President and Corporate Secretary






                                PAGE 8 OF 9 PAGES




EXHIBIT A

                             JOINT FILING AGREEMENT
                             ----------------------

         Manulife Financial Corporation, John Hancock Financial Services, Inc.,
John Hancock Life Insurance Company, John Hancock Subsidiaries, LLC, The
Berkeley Financial Group, LLC and John Hancock Advisers, LLC agree that the
Initial Schedule 13G to which this Agreement is attached, relating to the Common
Stock of Caliper Life Sciences Inc is filed on behalf of each of them.


                                                     Manulife Financial Corporation


                                                     By:      /s/Christer V. Ahlvik
                                                              ------------------------------------------------------
                                                              Name:   Christer V. Ahlvik
Dated:  February 3, 2005                                      Title:  Vice President and Corporate Secretary

                                                     John Hancock Financial Services, Inc.


                                                     By:      /s/Emanuel Alves
                                                              ------------------------------------------------------
                                                              Name:    Emanuel Alves
Dated:  February 3, 2005                                      Title:   Vice President and Corporate Secretary

                                                     John Hancock Advisers, LLC


                                                     By:      /s/Susan S. Newton
                                                              ------------------------------------------------------
                                                              Name:    Susan S. Newton
Dated:  February 3, 2005                                      Title:   Senior Vice President and Corporate Secretary






                                PAGE 9 OF 9 PAGES