PAGE 1
000 A000000 06/30/2013
000 C000000 0001216583
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 NUVEEN MULTI-STRATEGY INCOME & GROWTH FUND
001 B000000 811-21293
001 C000000 3129178200
002 A000000 333 WEST WACKER DRIVE
002 B000000 CHICAGO
002 C000000 IL
002 D010000 60606
002 D020000 1286
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
008 A000001 NUVEEN FUND ADVISORS, LLC
008 B000001 A
008 C000001 801-14147
008 D010001 CHICAGO
008 D020001 IL
008 D030001 60606
008 D040001 1286
008 A000002 NWQ INVESTMENT MANAGEMENT COMPANY, LLC
008 B000002 S
008 C000002 801-61379
008 D010002 LOS ANGELES
008 D020002 CA
008 D030002 90067
008 A000003 NUVEEN ASSET MANAGEMENT, LLC
008 B000003 S
008 C000003 801-71957
008 D010003 CHICAGO.
008 D020003 IL
008 D030003 60606
008 D040003 1286
012 A000001 COMPUTERSHARE
012 B000001 84-05925
012 C010001 PROVIDENCE
012 C020001 RI
012 C030001 02940
013 A000001 ERNST & YOUNG LLP
013 B010001 CHICAGO
PAGE 2
013 B020001 IL
013 B030001 60606
014 A000001 NUVEEN INVESTMENTS, LLC
014 B000001 8-13464
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02110
015 E010001 X
018 000000 Y
019 A000000 Y
019 B000000 211
019 C000000 NUVEENFUND
020 A000001 DEUTSCHE BANK
020 B000001 13-2730828
020 C000001 16
020 A000002 CREDIT RESEARCH
020 B000002 06-1386357
020 C000002 12
020 A000003 SANDLER O'NEILL
020 B000003 13-3481277
020 C000003 12
020 A000004 OPPENHEIMER
020 B000004 13-2798343
020 C000004 11
020 A000005 KNIGHT CAPITAL
020 B000005 22-3660471
020 C000005 9
020 A000006 B. RILEY & CO LLC
020 B000006 26-0673644
020 C000006 8
020 A000007 MACQUARIE GROUP
020 B000007 98-0141094
020 C000007 7
020 A000008 PICKERINGENERGY PARTNERS, INC
020 C000008 4
020 A000009 CIBC
020 B000009 13-2798343
020 C000009 4
020 A000010 MORGAN STANLEY
020 B000010 13-2655998
020 C000010 4
021 000000 112
022 A000001 WELLS FARGO
022 B000001 41-1508325
022 C000001 18640
022 D000001 35111
022 A000002 CITIGROUP
022 B000002 13-3214963
022 C000002 38774
PAGE 3
022 D000002 11385
022 A000003 UBS
022 B000003 13-2638166
022 C000003 12132
022 D000003 31964
022 A000004 MORGAN STANLEY
022 B000004 13-2655998
022 C000004 32863
022 D000004 6737
022 A000005 HSBC
022 B000005 13-2650272
022 C000005 30341
022 D000005 6961
022 A000006 BARCLAYS BANK PLC
022 B000006 13-4942190
022 C000006 23889
022 D000006 12911
022 A000007 JEFFERIES & CO
022 B000007 95-2622900
022 C000007 13467
022 D000007 22681
022 A000008 JP MORGAN CHASE
022 B000008 13-3224016
022 C000008 20611
022 D000008 10703
022 A000009 CREDIT SUISSE
022 B000009 13-5659485
022 C000009 0
022 D000009 26330
022 A000010 GOLDMAN SACHS
022 B000010 13-5108880
022 C000010 19965
022 D000010 660
023 C000000 334697
023 D000000 259112
024 000000 N
026 A000000 N
026 B000000 N
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
028 A010000 0
028 A020000 0
028 A030000 0
028 A040000 0
028 B010000 0
PAGE 4
028 B020000 0
028 B030000 0
028 B040000 0
028 C010000 0
028 C020000 0
028 C030000 0
028 C040000 0
028 D010000 0
028 D020000 0
028 D030000 0
028 D040000 0
028 E010000 0
028 E020000 0
028 E030000 0
028 E040000 0
028 F010000 0
028 F020000 0
028 F030000 0
028 F040000 0
028 G010000 0
028 G020000 0
028 G030000 0
028 G040000 0
028 H000000 0
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
035 000000 0
036 B000000 0
038 000000 0
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 N
048 000000 0.000
048 A010000 0
048 A020000 0.000
048 B010000 0
PAGE 5
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 Y
053 A000000 N
054 A000000 Y
054 B000000 N
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 Y
055 A000000 Y
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 0
062 A000000 N
062 B000000 0.0
062 C000000 0.0
PAGE 6
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
063 A000000 0
063 B000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 Y
066 G000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 Y
070 B010000 Y
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 N
070 L010000 Y
PAGE 7
070 L020000 N
070 M010000 Y
070 M020000 N
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 N
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000 334697
071 B000000 337076
071 C000000 1406357
071 D000000 24
072 A000000 6
072 B000000 23588
072 C000000 24615
072 D000000 0
072 E000000 0
072 F000000 5824
072 G000000 0
072 H000000 0
072 I000000 2
072 J000000 126
072 K000000 39
072 L000000 78
072 M000000 17
072 N000000 0
072 O000000 0
072 P000000 2303
072 Q000000 0
072 R000000 23
072 S000000 19
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 88
072 X000000 8519
072 Y000000 0
072 Z000000 39684
072AA000000 27817
072BB000000 0
072CC010000 0
072CC020000 28830
072DD010000 368369
072DD020000 0
072EE000000 0
073 A010000 0.3798
PAGE 8
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 0
074 B000000 36154
074 C000000 0
074 D000000 82692
074 E000000 638881
074 F000000 27519
074 G000000 0
074 H000000 0
074 I000000 610835
074 J000000 4390
074 K000000 0
074 L000000 15695
074 M000000 9334
074 N000000 1425500
074 O000000 13284
074 P000000 955
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 411942
074 S000000 0
074 T000000 999319
074 U010000 96990
074 U020000 0
074 V010000 10.30
074 V020000 0.00
074 W000000 0.0000
074 X000000 150
074 Y000000 516748
075 A000000 1024806
075 B000000 0
076 000000 9.55
077 A000000 N
078 000000 N
080 C000000 0
081 B000000 0
082 B000000 0
083 B000000 0
084 B000000 0
086 A010000 0
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
PAGE 9
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 67073B106
087 A030000 JPC
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 Y
SIGNATURE STEPHEN D. FOY
TITLE VP & CONTROLLER