UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 _____________________ FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES AND EXCHANGE ACT OF 1934 November 21, 2002 Date of Report (Date of earliest event reported) _____________________ NEOTHERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 000-28782 93-0979187 (State or other Jurisdiction (Commission File Number) (IRS Employer of Incorporation) Identification Number) 157 Technology Drive 92618 Irvine, California (Zip Code) (Address of principal executive offices) (949) 788-6700 (Registrant's telephone number, including area code) N/A (Former Name or Former Address, if Changed Since Last Report Item 5. Other Events On November 21, 2002, NeoTherapeutics, Inc. ("NeoTherapeutics") issued a press release announcing that it had issued 356,956 shares of common stock in a private placement to settle $628,190.09 in vendor payables. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by this reference. Item 7(c). Exhibits Exhibits: -------- 4.1 Form of Settlement Agreement and Release 4.2 Settlement Agreement and Release dated as of October 22, 2002 by and between NeoTherapeutics, Inc. and Symbion Research International, Inc. 99.1 Press release dated November 21, 2002 SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. NEOTHERAPEUTICS, INC. Date: November 21, 2002 By: /s/ Rajesh C. Shrotriya ----------------------------------- Name: Rajesh C. Shrotriya, M.D. Title: Chairman of the Board, Chief Executive Officer and President EXHIBIT INDEX Exhibits: -------- 4.1 Form of Settlement Agreement and Release 4.2 Settlement Agreement and Release dated as of October 22, 2002 by and between NeoTherapeutics, Inc. and Symbion Research International, Inc. 99.1 Press release dated November 21, 2002