SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Schedule 13G
Under the Securities
Exchange Act of 1934
(Amendment No.:2 )*
Name of issuer: BIOMARIN PHARMACEUTICALS INC
Title of Class of Securities: Common Stock
CUSIP Number: 09061G101
Date of Event Which Requires Filing of this Statement: December 31, 2005
Checkthe appropriate box to designate the rule pursuant to which this Schedule is filed: (X) Rule 13d-1(b) ( ) Rule 13d-1(c)( ) Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
(Continued on the following page(s))
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13G
CUSIP No.: 09061G101
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
VANGUARD HORIZON FUNDS - VANGUARD CAPITAL OPPORTUNITY FUND 23-2801541
2. CHECK THE APPROPRIATE [LINE] IF A MEMBER OF A GROUP
A. B. X
3. SEC USE ONLY
4. CITIZENSHIP OF PLACE OF ORGANIZATION
Delaware
(For questions 5-8, report the number of shares beneficially owned by each reporting person with:)
5. SOLE VOTING POWER
4670500
6. SHARED VOTING POWER
0
7. SOLE DISPOSITIVE POWER
0
8. SHARED DISPOSITIVE POWER
0
9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
4670500
10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
N/A
11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
6.32%
12. TYPE OF REPORTING PERSON
IV
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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_________________
SCHEDULE 13G
Under the Securities Act of 1934
_________________
Check the following [line] if a fee is being paid with this statement N/A
Item 1(a) — Name of Issuer:
BIOMARIN PHARMACEUTICALS INC
Item 1(b) — Address of Issuer’s Principal Executive Offices:
105
Digital Drive
Novato, CA 94949
Item 2(a) — Name of Person Filing:
VANGUARD HORIZON FUNDS - VANGUARD CAPITAL OPPORTUNITY FUND 23-2801541
Item 2(b) – Address of Principal Business Office or, if none, residence:
100
Vanguard Blvd.
Malvern, PA 19355
Item 2(c) – Citizenship:
Delaware
Item 2(d) — Title of Class of Securities:
Common Stock
Item 2(e) — CUSIP Number
09061G101
Item 3 — Type of Filing:
This statement is being filed pursuant to Rule 13d-1. Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).
Item 4 — Ownership:
(a) Amount Beneficially Owned:
4670500
(b) Percent of Class:
6.32
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(c) Number of shares as to which such person has:
(i) sole power to vote or direct to vote: 4670500
(ii) shared power to vote or direct to vote: 0
(iii) sole power to dispose of or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 0
Item 5 — Ownership of Five Percent or Less of a Class:
Not Applicable
Item 6 — Ownership of More Than Five Percent on Behalf of Another Person:
Not applicable
Item 7 — Identification and Classification of the Subsidiary Which Acquired The Security Being Reported on by the Parent Holding Company:
Not applicable
Item 8 — Identification and Classification of Members of Group:
Not applicable
Item 9 — Notice of Dissolution of Group:
Not applicable
Item 10 — Certification:
By signing below I certify than, to the best of my knowledge and belief, the securities referred to above were acquired in the ordinary course of business and were not acquired for the purpose of and do not have the effect of changing or influencing the control of the issuer of such securities and were not acquired in connection with or as a participant in any transaction having such purpose or effect.
Signature
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: February 13, 2006
Name: Christopher Wightman
Title: Assistant Secretary
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