UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of earliest event reported): December 6, 2006

                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)


           Delaware                       0-16132                22-2711928
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(State or other jurisdiction of   (Commission File Number)     (IRS Employer
        incorporation)                                       Identification No.)


     86 Morris Avenue, Summit, New Jersey                           07901
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   (Address of principal executive offices)                       (Zip Code)

       Registrant's telephone number, including area code: (908) 673-9000

          ------------------------------------------------------------
         (Former name or former address, if changed since last report.)




Check the appropriate box below if the Form 8-K filing is intended to
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[_]  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

[_]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
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[_]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[_]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))








ITEM 5.02   DEPARTURE OF DIRECTORS OR PRINCIPAL OFFICERS; ELECTION OF DIRECTORS;
            APPOINTMENT OF PRINCIPAL OFFICERS; COMPENSATORY ARRANGEMENTS OF
            CERTAIN OFFICERS.

            APPOINTMENT OF CHIEF FINANCIAL OFFICER

            On December 7, 2006, Celgene Corporation announced the appointment
            of David W. Gryska as Chief Financial Officer. Mr. Gryska will lead
            the worldwide finance organization, which includes accounting and
            reporting, strategic planning and analysis, treasury, tax, audit,
            and corporate communications. In connection with this appointment,
            Mr. Gryska will receive an annual base salary of $450,000; will be
            eligible to participate in the Management Incentive Plan with an
            incentive target equal to 50% of his annual base salary and maximum
            award equal to 200% of the target award; is expected to participate
            in the 2007 - 2009 Long Term Incentive Plan, or LTIP, with a payout
            targeted at 50% of his annual base salary and a maximum potential
            payout of 100% of his annual base salary contingent upon approval of
            the plan by the Compensation Committee. Payout under the 2007 - 2009
            LTIP Plan is in 2010 contingent upon achievement of established
            goals. Mr. Gryska has also been granted the option to purchase
            25,000 shares of Celgene Corporation common stock and will be
            granted an additional 25,000 options pursuant to the 1998 Stock
            Incentive Plan on March 6, 2007, June 6, 2007 and September 6, 2007.

            Attached hereto and incorporated herein by reference as Exhibit 99.1
            is the Press Release announcing the appointment.

ITEM 9.01   FINANCIAL STATEMENTS AND EXHIBITS.

            Exhibits

            99.1 - Press Release dated December 7, 2006 announcing the
                   appointment of David W. Gryska as Chief Financial Officer.





                                   SIGNATURES

Pursuant to the requirements of the Securities and Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                              CELGENE CORPORATION

Date: December 7, 2006                        By: /s/ Robert J. Hugin
                                              ----------------------------------
                                                  Name:  Robert J. Hugin
                                                  Title: President and
                                                         Chief Operating Officer






EXHIBIT INDEX


EXHIBIT NO.      DESCRIPTION
-----------      -----------

   99.1          Press release dated December 7, 2006 announcing the appointment
                 of David W. Gryska as Chief Financial Officer.