UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934




         Date of Report (Date of earliest event reported): June 29, 2006

                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)


          Delaware                       0-16132                 22-2711928
-----------------------------   ------------------------   ---------------------
(State or other jurisdiction    (Commission File Number)       (IRS Employer
     of incorporation)                                       Identification No.)

          86 Morris Avenue, Summit, New Jersey                    07901
--------------------------------------------------------   ---------------------
        (Address of principal executive offices)                (Zip Code)

Registrant's telephone number, including area code: (908) 673-9000

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   (Former name or former address, if changed since last report.)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))



ITEM 8.01   OTHER EVENTS

On June 29, 2006,  Celgene  Corporation  announced  that the U.S.  Food and Drug
Administration  has granted  approval for its  Supplemental New Drug Application
for  an  additional  indication  for  REVLIMID(R)  (lenalidomide),  for  use  in
combination with dexamethasone as a treatment for patients with multiple myeloma
who have received at least one prior therapy.  Attached hereto and  incorporated
by reference as Exhibit 99.1 is the press release announcing such information.

ITEM 9.01   FINANCIAL STATEMENTS AND EXHIBITS

          (d)  Exhibit 99.1 - Press Release Dated June 29, 2006



                                   SIGNATURES

Pursuant to the  requirements  of the  Securities  and Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                        CELGENE CORPORATION



Date:  June 29, 2006                    By:   /s/ Robert J. Hugin
----------------------                  ----------------------------
                                        Name:  Robert J. Hugin
                                        Title: President and
                                        Chief Operating Officer