UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934


                          SPECTRUM PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    84763A108
--------------------------------------------------------------------------------
                                 (CUSIP Number)

   Mitchell D. Kaye, Manager                        with a copy to:
   Xmark Asset Management, LLC                      Steven E. Seisser, Esq.
   152 West 57th Street                             Lowenstein Sandler PC
   21st Floor                                       65 Livingston Avenue
   New York, New York  10019                        Roseland, New Jersey  07068
   (212) 247-8200                                   (973) 597-2506
--------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  September 20, 2004
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.         84763A108
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not 
         (b)               Applicable
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3.  SEC Use Only
--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  WC
--------------------------------------------------------------------------------
5.  Check if  Disclosure  of  Legal  Proceedings Is  Required Pursuant  to Items
    2(d) or 2(e):                 Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:  New York, United States
--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:                  *
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:             *
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:          *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:  714,283*
--------------------------------------------------------------------------------
12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares
    (See Instructions):          Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):  5.0%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  IA
--------------------------------------------------------------------------------

* The  reporting  person is Xmark  Asset  Management,  LLC  ("XAM"),  a New York
limited liability company.  XAM's interest in the securities  reported herein is
limited to its  pecuniary  interest,  if any,  in Xmark Fund,  L.P.,  a Delaware
limited  partnership  ("Xmark  LP"),  and Xmark  Fund,  Ltd.,  a Cayman  Islands
exempted company ("Xmark Ltd").

Xmark LP is the holder of: (i) 352,294  shares (the "Xmark LP Shares") of Common
Stock,   par  value  $0.001  per  share  (the  "Common   Stock"),   of  Spectrum
Pharmaceuticals,  Inc., a Delaware  corporation (the  "Company");  (ii) warrants
(the "2003 Xmark LP Warrants") which,  subject to certain exercise  restrictions
contained  therein,  entitle  Xmark LP to purchase an aggregate of up to 168,000
shares of Common Stock at an exercise  price of $6.50 per share (the "2003 Xmark
LP Warrant Shares"),  which exercise price is subject to adjustment as set forth
in the 2003 Xmark LP Warrants; and (iii) warrants (the "2004 Xmark LP Warrants")
which, subject to certain exercise restrictions contained therein, entitle Xmark
LP to  purchase  an  aggregate  of up to 53,666  shares  of  Common  Stock at an
exercise price of $10.00 per share (the "2004 Xmark LP Warrant  Shares"),  which
exercise  price is  subject  to  adjustment  as set  forth in the 2004  Xmark LP
Warrants.

Xmark Ltd is the holder of: (i) 361,989  shares of Common  Stock (the "Xmark Ltd
Shares," and together  with the Xmark LP Shares,  the  "Shares");  (ii) warrants
(the "2003 Xmark Ltd  Warrants,"  and together  with the 2003 Xmark LP Warrants,
the "2003 Warrants") which, subject to certain exercise  restrictions  contained
therein,  entitle Xmark Ltd to purchase an aggregate of up to 252,000  shares of
Common  Stock at an  exercise  price of $6.50 per  share  (the  "2003  Xmark Ltd




Warrant  Shares,"  and  together  the 2003  Xmark LP Warrant  Shares,  the "2003
Warrant Shares"),  which exercise price is subject to adjustment as set forth in
the 2003  Xmark Ltd  Warrants;  and (iii)  warrants  which,  subject  to certain
exercise  restrictions  contained  therein,  entitle  Xmark Ltd to  purchase  an
aggregate of up to 51,335 shares of Common Stock at an exercise  price of $10.00
per share (the "2004 Xmark Ltd Warrant  Shares,"  and together the 2004 Xmark LP
Warrant Shares,  the "2004 Warrant Shares"),  which exercise price is subject to
adjustment as set forth in the 2004 Xmark Ltd Warrants.

The 2003 Warrants and the 2004 Warrants each provide that in no event shall such
warrants  be  exercisable  for  shares of Common  Stock to the  extent  that the
issuance of Common Stock thereunder  would result in the "beneficial  ownership"
(as defined in Section 13(d) of the Securities Exchange Act of 1934, as amended,
and Regulations  13D-G  thereunder) by Xmark LP, Xmark Ltd, or their affiliates,
of more than 4.95% and 4.99%,  respectively,  of the Common Stock (the "Issuance
Limitation").  The Issuance Limitation may not be waived.

XAM serves as  investment  manager  for each of Xmark LP and Xmark Ltd.  In such
capacity,  XAM  possesses  the power to vote and direct the  disposition  of all
securities  held by Xmark LP and Xmark Ltd.  Thus,  as of September 20, 2004 for
the purposes of Reg.  Section  240.13d-3,  XAM may be deemed to beneficially own
714,283  shares of Common  Stock,  or 5.0% of the Common Stock deemed issued and
outstanding as of that date.





Item 1.   Security and Issuer.
          -------------------

          This statement relates to the common stock, par value $0.001 per share
(the "Common Stock"), of Spectrum Pharmaceuticals,  Inc., a Delaware corporation
(the "Company").  The Company has its principal executive offices located at 157
Technology Drive, Irvine, California 92618.


Item 2.   Identity and Background.
          -----------------------

          The person filing this statement is Xmark Asset Management, LLC, a New
York limited liability company ("XAM").  XAM's business address is 152 West 57th
Street, 21st Floor, New York, New York 10019.

          XAM serves as the investment  manager for Xmark Fund, L.P., a Delaware
limited  partnership  ("Xmark LP") and Xmark Fund, Ltd., a Cayman Islands exempt
company  ("Xmark Ltd").  Xmark LP and Xmark Ltd are engaged in the investment in
personal  property of all kinds,  including  but not  limited to capital  stock,
depository  receipts,   investment  companies,   mutual  funds,   subscriptions,
warrants,  bonds,  notes,  debentures,  options and other securities of whatever
kind and nature.

          Mitchell  D.  Kaye,   whose  business   address  is  c/o  Xmark  Asset
Management,  LLC, 152 West 57th Street, 21st Floor, New York, New York 10019, is
the Chief Investment Officer of Xmark LP and Xmark Ltd and the Manager of XAM.

          XAM has never been  convicted  in any criminal  proceeding  (excluding
traffic  violations  or  similar  misdemeanors),  nor has it been a party to any
civil proceeding commenced before a judicial or administrative body of competent
jurisdiction as a result of which it was or is now subject to a judgment, decree
or final order  enjoining  future  violations  of, or  prohibiting  or mandating
activities subject to, federal or state securities laws or finding any violation
with respect to such laws.

          Mr.  Kaye  has  never  been  convicted  in  any  criminal   proceeding
(excluding traffic violations or similar misdemeanors),  nor has he been a party
to any civil proceeding  commenced before a judicial or  administrative  body of
competent  jurisdiction  as a  result  of which  he was or is now  subject  to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, federal or state securities laws or finding
any  violation  with  respect to such laws.  Mr. Kaye is a citizen of the United
States.


Item 3.   Source and Amount of Funds or Other Consideration.
          ------------------------------------------------- 

          The source of the funds used in making the  purchases of the Company's
Common Stock was XAM's working capital.





Item 4.   Purpose of Transaction.
          ---------------------- 

          The acquisition of the securities referred to herein is for investment
purposes. XAM has no present plans or intentions which relate to or would result
in any of the transactions required to be described in Item 4 of Schedule 13D.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------ 

          Based  upon  the  Company's  Quarterly  Report  on Form  10-Q  for the
quarterly  period  ended  June 30,  2004,  as of  August  12,  2004  there  were
14,184,452  shares of Common Stock issued and  outstanding.  As of September 20,
2004, Xmark LP and Xmark Ltd beneficially own 714,283 shares of Common Stock.

          As of September 20, 2004, Xmark LP is the holder of (i) 352,294 shares
of Common Stock of the Company, (ii) warrants which, subject to certain exercise
restrictions contained therein,  entitle Xmark LP to purchase up to an aggregate
of 168,000  shares of Common Stock at an exercise  price of $6.50 per share (the
"2003 Xmark LP Warrants"),  which exercise price is subject to adjustment as set
forth in the 2003  Xmark LP  Warrants,  and (iii)  warrants  which,  subject  to
certain exercise restrictions contained therein, entitle Xmark LP to purchase up
to an aggregate of 53,666 shares of Common Stock at an exercise  price of $10.00
per share (the "2004 Xmark LP  Warrants",  and  together  with the 2003 Xmark LP
Warrants,  the  "Xmark  LP  Warrants"),  which  exercise  price  is  subject  to
adjustment  as set forth in the 2004 Xmark LP Warrants.  Xmark Ltd is the holder
of (i)  361,989  shares of Common  Stock and (ii)  warrants  which,  subject  to
certain exercise restrictions  contained therein,  entitle Xmark Ltd to purchase
up to an  aggregate of 252,000  shares of Common  Stock at an exercise  price of
$6.50 per share (the "2003 Xmark Ltd Warrants"), which exercise price is subject
to adjustment as set forth in the 2003 Xmark Ltd  Warrants,  and (iii)  warrants
which, subject to certain exercise restrictions contained therein, entitle Xmark
Ltd to  purchase  up to an  aggregate  of 51,335  shares  of Common  Stock at an
exercise price of $10.00 per share (the "2004 Xmark Ltd Warrants",  and together
with the 2003 Xmark Ltd  Warrants,  the "Xmark Ltd  Warrants"),  which  exercise
price is subject to adjustment as set forth in the Xmark Ltd Warrants.

          The 2003  Warrants and the 2004 Warrants each provide that in no event
shall such warrants be exercisable for shares of Common Stock to the extent that
the  issuance  of  Common  Stock  thereunder  would  result  in the  "beneficial
ownership" (as defined in Section 13(d) of the Securities  Exchange Act of 1934,
as amended,  and Regulations  13D-G thereunder) by Xmark LP, Xmark Ltd, or their
affiliates, of more than 4.95% and 4.99%, respectively, of the Common Stock (the
"Issuance  Limitation").  The Issuance Limitation may not be waived. Thus, as of
September  20, 2004,  for the  purposes of Reg. Section  240.13d-3,  XAM  may be
deemed to beneficially own 714,283 shares of Common Stock, or 5.0% of the Common
Stock  deemed  issued and  outstanding  as of that date.  The  reporting  person
acquired a portion of the shares of Common Stock, the 2004 Xmark LP Warrants and
the 2004 Xmark Ltd Warrants in a private placement  transaction disclosed by the
Company on its current  report on Form 8-K dated as of April 21, 2004,  as filed
with the Securities and Exchange Commission on April 23, 2004.

          The following table details the transactions  during the 60 days prior
to and including  September 20, 2004 in Common Stock, or securities  convertible
into,  exercisable for or exchangeable for Common Stock, by XAM or any person or





entity  controlled by XAM or any person or entity for which XAM possesses voting
or investment control over the securities thereof (each of which was effected in
an ordinary brokerage transaction).

                                   I. Xmark LP

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   7/22/2004                         2,096                     $4.93
   7/23/2004                         6,900                     $4.79
   7/26/2004                         8,995                     $4.57
   7/27/2004                         3,322                     $4.38
   7/28/2004                         4,971                     $4.20
   7/29/2004                         2,044                     $4.22
   7/30/2004                        12,778                     $4.80
   7/30/2004                        10,222                     $4.97
   8/03/2004                            51                     $5.62
   8/06/2004                        12,778                     $4.88
   8/09/2004                        10,222                     $4.83
   8/10/2004                         3,067                     $4.98
   8/11/2004                         8,838                     $4.82
   8/12/2004                         5,111                     $5.02
   8/13/2004                         2,555                     $4.99
   8/16/2004                         5,111                     $5.18
   8/17/2004                         5,093                     $5.24
   8/18/2004                         3,578                     $5.41
   8/19/2004                         2,556                     $5.29
   8/19/2004                         2,556                     $5.28
   8/20/2004                         9,404                     $5.36
   8/23/2004                         2,760                     $5.84
   8/24/2004                         8,484                     $5.37
   8/25/2004                         7,667                     $5.43
   8/27/2004                         2,556                     $5.58
   8/30/2004                        12,778                     $6.01
   9/03/2004                         4,089                     $6.02
   9/07/2004                         9,813                     $6.35
   9/09/2004                         5,315                     $6.24
   9/10/2004                         4,089                     $6.36
   9/10/2004                         5,110                     $6.24
   9/17/2004                         1,584                     $6.40
   9/20/2004                        11,193                     $6.34
   9/20/2004                         6,082                     $6.25




                                     (Sales)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------
   8/09/2004                         2,555                       $4.72
   8/20/2004                         2,249                       $5.70


                                  II. Xmark Ltd

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------
   7/22/2004                         2,004                       $4.93
   7/23/2004                         6,600                       $4.79
   7/26/2004                         8,605                       $4.57
   7/27/2004                         3,178                       $4.38
   7/28/2004                         4,755                       $4.20
   7/29/2004                         1,956                       $4.22
   7/30/2004                        12,223                       $4.80
   7/30/2004                         9,778                       $4.97
   8/03/2004                            49                       $5.62
   8/06/2004                        12,222                       $4.88
   8/09/2004                         9,778                       $4.83
   8/10/2004                         2,933                       $4.98
   8/11/2004                         8,454                       $4.82
   8/12/2004                         4,889                       $5.02
   8/13/2004                         2,445                       $4.99
   8/16/2004                         4,889                       $5.18
   8/17/2004                         4,871                       $5.24
   8/18/2004                         3,422                       $5.41
   8/19/2004                         2,444                       $5.29
   8/19/2004                         2,444                       $5.28
   8/20/2004                         8,996                       $5.36
   8/23/2004                         2,640                       $5.84
   8/24/2004                         8,116                       $5.37
   8/25/2004                         7,333                       $5.43
   8/27/2004                         2,444                       $5.58
   8/30/2004                        12,222                       $6.01
   8/31/2004                        25,000                       $6.30
   9/03/2004                         3,911                       $6.02
   9/07/2004                         9,387                       $6.35
   9/09/2004                         5,085                       $6.24
   9/10/2004                         3,911                       $6.36
   9/10/2004                         4,890                       $6.24
   9/17/2004                         1,516                       $6.40
   9/20/2004                        10,707                       $6.34
   9/20/2004                         5,818                       $6.25



                                     (Sales)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------
   8/09/2004                         2,445                       $4.72
   8/20/2004                         2,151                       $5.70



Item 6.   Contracts, Arrangements, Understandings or  Relationships With Respect
          to Securities of the Issuer.
          ----------------------------------------------------------------------

          None.


Item 7.   Material to be Filed as Exhibits.
          --------------------------------

          None.



                                    Signature
                                    ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                            December 10, 2004

                                            XMARK ASSET MANAGEMENT, LLC

                                            /s/ Mitchell D. Kaye 
                                            ------------------------------------
                                            Mitchell D. Kaye, Manager


Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).