SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                          (Amendment No.__22__)



                            Interneuron Pharmaceuticals, Inc.
              -----------------------------------------------------
                                (Name of Issuer)

                     Common Stock, $.001 par value ("the shares")
            --------------------------------------------------------
                         (Title of Class of Securities)

                                  460573108
           ----------------------------------------------------------
                                 (CUSIP Number)

                David Selengut, Esq. at Ellenoff Grossman Schole & Cyruli LLP
                370 Lexington Avenue  NY NY  10017  212-370-1300
         ------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                 Authorized to Receive Notices and Communications)

                             December 28, 2000
          -----------------------------------------------------------
            (Date of Event which Requires FIling of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b) or 13d-1(g), check the following box [ ].

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).







                             Page 1 of 4 pages





CUSIP No.  460573108                13D                   Page 2 of 4 pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       J. Morton Davis



--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [x ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY


-------------------------------------------------------------------------------
   4   Source of Funds

       N/A

-------------------------------------------------------------------------------
   5   Check Box if  Disclosure  of Legal  Proceedings  is required  pursuant to
       Items 2(d) or 2(e)


-------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       United States

--------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            3,801,587
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             677,865
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             3,801,587
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       677,865
--------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       4,479,452
--------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


--------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                       10.5%
-------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

                    IN
--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT




CUSIP No.  460573108                 13D           Page 3 of 4 pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       D.H. Blair Investment Banking Corp.


--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [X ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY


-------------------------------------------------------------------------------
   4   Source of Funds

       N/A

-------------------------------------------------------------------------------
   5   Check Box if  Disclosure  of Legal  Proceedings  is required  pursuant to
       Items 2(d) or 2(e)


-------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware

--------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            3,751,431
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             0
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             3,751,431
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       0
--------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       3,751,431
--------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


--------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                    8.8%
--------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*
                    BD

--------------------------------------------------------------------------------
                    *SEE INSTRUCTIONS BEFORE FILLING OUT



                                                  Page 4 of 4 pages
Schedule 13D is hereby amended as follows:



               J. Morton  Davis and D.H.  Blair  Investment  Banking  Corp.
               ("Blair Investment") (together, the "Reporting Parties").

Item 5. (a) is hereby amended in its entirety as follows:

          As of December 28, 2000, Mr. Davis may be deemed to  beneficially
          own  4,479,452  shares  or 10.5% of the  Issuer's  shares  issued  and
          outstanding as follows: (i) 50,156 shares owned directly by Mr. Davis,
          (ii)  3,751,431  shares owned by Blair  Investment,  and (iii) 677,865
          shares owned by Rivkalex Corporation (1).

          As of  December 28,  2000,  Blair  Investment  may be  deemed  to
          beneficially  own 3,751,431  shares or 8.8% of the Issuer's shares
          as indicated in (ii) above.


Item 5. (b) in hereby amended in its entirety as follows:

          Mr.  Davis  has sole  power to vote or to  direct  the  vote,  to
          dispose or to direct the disposition of those shares owned directly by
          him and those  owned by Blair  Investment.  Rosalind  Davidowitz,  Mr.
          Davis' wife, has sole power to dispose or to direct the disposition of
          those shares owned by Rivkalex Corporation.


Item 5 (c) is hereby amended in its entirety as follows:

          On December  28,  2000,  Blair  Investment  sold an  aggregate of
          3,600,000  shares  to  three  individuals  for $.90  per  share.  Each
          purchaser   paid  $100,000  of  the  purchase  price  and  executed  a
          promissory  note  for  the  remainder  of  the  purchase  price.   The
          promissory  notes are due December  30, 2002 and bear  interest at the
          annual rate of 6.5%.

          On December 28, 2000, J. Morton Davis sold 80,000 shares to each of
          the purchasers described in the preceding paragraph for $.90 a share.


                              SIGNATURES

After reasonable  inquiry and to the best of my knowledge and belief, we certify
that the information set forth in this statement is true, complete and correct.



                                       /s/ J. Morton Davis
Date:    December 20, 2000              ________________________
         New York, New York                J. Morton Davis





                                       D.H. BLAIR INVESTMENT BANKING CORP.





                                   by: /s/ David Nachamie
Date:    December 20, 2000               _____________________________
         New York, New York                David Nachamie
                                           Treasurer

____________________________________________________________________________

(1)  Rivkalex  Corporation  ("Rivkalex")  is  a  private  corporation  owned  by
     Rosalind  Davidowitz.  Filing  of this  statement  shall  not be  deemed an
     admission  by J.  Morton  Davis that he  beneficially  owns the  securities
     attributed to Rivkalex for any purpose. J. Morton Davis expressly disclaims
     beneficial ownership of all securities held by Rivkalex for any purpose.