Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Cayer Paul E
 2. Date of Event Requiring Statement (Month/Day/Year)
08/12/2014		 3. Issuer Name and Ticker or Trading Symbol
Otonomy, Inc. [OTIC]
(Last)
(First)
(Middle)
C/O OTONOMY, INC., 6275 NANCY RIDGE DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
CFO/Ch. Business Offcr & Sec.
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

SAN DIEGO, CA 92121		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 7,110
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (1) 06/16/2020 Common Stock 8,532 $ 2.82 D  
Employee Stock Option (right to buy)   (2) 11/19/2020 Common Stock 29,863 $ 3.17 D  
Employee Stock Option (right to buy)   (3) 09/18/2022 Common Stock 19,908 $ 1.06 D  
Employee Stock Option (right to buy)   (4) 12/20/2023 Common Stock 141,541 $ 1.76 D  
Employee Stock Option (right to buy)   (5) 06/03/2024 Common Stock 85,039 $ 6.33 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Cayer Paul E
C/O OTONOMY, INC.
6275 NANCY RIDGE DRIVE
SAN DIEGO, CA 92121		       CFO/Ch. Business Offcr & Sec.  

Signatures

/s/ Paul E. Cayer 08/12/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) One-fourth of the shares subject to the option vested on June 16, 2011 and one forty-eighth of the shares vest monthly thereafter.
(2) One-fourth of the shares subject to the option vested on November 19, 2011 and one forty-eighth of the shares vest monthly thereafter.
(3) One-fourth of the shares subject to the option vested on September 18, 2013 and one forty-eighth of the shares vest monthly thereafter.
(4) One-fourth of the shares subject to the option vest on September 1, 2014 and one forty-eighth of the shares vest monthly thereafter.
(5) One-fourth of the shares subject to the option vest on April 23, 2015 and one forty-eighth of the shares vest monthly thereafter.
 
Remarks:
Exhibit 24 - Power of Attorney

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