FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * GRAZIANO CHANE   2. Issuer Name and Ticker or Trading Symbol HARVARD BIOSCIENCE INC [HBIO] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 84 OCTOBER HILL ROAD 3. Date of Earliest Transaction (Month/Day/Year) 07/25/2013 (Street) HOLLISTON, MA 01746 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 07/25/2013   M   400,000 A $ 3.18 2,906,865 D   Common Stock 07/25/2013   F   230,434 (1) D $ 5.52 2,676,431 D   Common Stock 07/25/2013   M   300,000 A $ 1.99 2,976,431 D   Common Stock 07/25/2013   F   108,152 (1) D $ 5.52 2,868,279 D   Common Stock 07/25/2013   M   125,000 A $ 4.01 2,993,279 D   Common Stock 07/25/2013   F   90,806 (1) D $ 5.52 2,902,473 D   Common Stock 07/25/2013   M   300,000 A $ 4.28 3,202,473 D   Common Stock 07/25/2013   F   232,608 (1) D $ 5.52 2,969,865 D   Common Stock 07/25/2013   M   125,000 A $ 2.98 3,094,865 D   Common Stock 07/25/2013   F   67,481 (1) D $ 5.52 3,027,384 D   Common Stock 07/25/2013   M   50,289 D $ 3.57 3,077,673 D   Common Stock 07/25/2013   F   32,523 (1) D $ 5.52 3,045,150 D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (right to buy)

$ 4.01

07/25/2013

M

125,000 (2)

08/04/2005

08/12/2013

Common Stock

125,000

$ 0

0

D

Stock Option (right to buy)

$ 3.18

07/25/2013

M

400,000 (2)

01/01/2010

08/12/2013

Common Stock

400,000

$ 0

0

D

Stock Option (right to buy)

$ 1.99

07/25/2013

M

300,000 (2)

01/01/2009

08/12/2013

Common Stock

300,000

$ 0

0

D

Stock Option (right to buy)

$ 4.28

07/25/2013

M

300,000 (2)

01/01/2007

08/12/2013

Common Stock

300,000

$ 0

0

D

Stock Option (right to buy)

$ 2.98

07/25/2013

M

125,000 (2)

01/01/2006

08/12/2013

Common Stock

125,000

$ 0

0

D

Stock Option (right to buy)

$ 3.57

07/25/2013

M

50,289 (2)

01/01/2013

08/12/2013

Common Stock

50,289

$ 0

0

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
GRAZIANO CHANE 84 OCTOBER HILL ROAD HOLLISTON, MA 01746		X

Signatures

Chane Graziano		07/31/2013
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Represents the number of shares of common stock that the Reporting Person attested to the ownership thereof in accordance with the Issuer's 2000 Stock Option and Incentive Plan, as amended, in connection with the payment of the option exercise price. With respect to each option exercise, the Issuer delivered the net amount of the option shares to the Reporting Person and such attestation shares were not sold by the Reporting Person or delivered to the Issuer. Nevertheless, the SEC deems such exercise and related attestation to be a disposition of shares for purposes of Section 16(a) of the Securities Exchange Act of 1934."
(2)	Represents exercise of stock options granted pursuant to the Issuer's 2000 Stock Option and Incentive Plan, as amended.

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