------------------------------ OMB APPROVAL OMB Number 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response . . . 11 ------------------------------ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL SCHEDULE 13G Under the Securities Exchange Act of 1934 Caliper Life Sciences, Inc. -------------------------------------------------------------------------------- (Name of Issuer) Common Stock -------------------------------------------------------------------------------- (Title of Class of Securities) 896095106 -------------------------------------------------------------------------------- (CUSIP Number) December 31, 2004 -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ X ] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). PAGE 1 OF 9 PAGES ----------------------------------------- -------------------------------------- CUSIP No. 896095106 13G Page 2 of 9 Pages ----------------------------------------- -------------------------------------- ---------- ------------------------------------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only). Manulife Financial Corporation I.R.S. No. ---------- ------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| N/A ---------- ------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY ---------- ------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ---------- ------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 1,832,812: 605 directly and 1,832,207 through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC Number of Shares Beneficially Owned by Each Reporting Person With -------- ------------------------------------------------------------------------------------------- 6 SHARED VOTING POWER -0- -------- ------------------------------------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 1,832,812: 605 directly and 1,832,207 through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC -------- ------------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER -0- ---------- ------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,832,812: 605 directly and 1,832,207 through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC ---------- ------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* N/A ---------- ------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.19%: .00002% directly and 6.19% through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC ---------- ------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* HC ---------- ------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! PAGE 2 OF 9 PAGES ----------------------------------------- -------------------------------------- CUSIP No. 896095106 13G Page 3 of 9 Pages ----------------------------------------- -------------------------------------- ---------- ------------------------------------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only). John Hancock Financial Services, Inc. I.R.S. No. 04-3483032 ---------- ------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| N/A ---------- ------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY ---------- ------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ---------- ------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- Number of Shares Beneficially Owned by Each Reporting Person With -------- ------------------------------------------------------------------------------------------- 6 SHARED VOTING POWER -0- -------- ------------------------------------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER -0- -------- ------------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER -0- ---------- ------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON None, except through its indirect, wholly-owned subsidiary, John Hancock Advisers, LLC ---------- ------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* N/A ---------- ------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 See line 9, above. ---------- ------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* HC ---------- ------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! PAGE 3 OF 9 PAGES ----------------------------------------- -------------------------------------- CUSIP No. 896095106 13G Page 7 of 9 Pages ----------------------------------------- -------------------------------------- ---------- ------------------------------------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only). John Hancock Advisers, LLC I.R.S. No. 04-2441573 ---------- ------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| N/A ---------- ------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY ---------- ------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ---------- ------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 1,832,207 Number of Shares Beneficially Owned by Each Reporting Person With -------- ------------------------------------------------------------------------------------------- 6 SHARED VOTING POWER -0- -------- ------------------------------------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 1,832,207 -------- ------------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER -0- ---------- ------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,832,207 ---------- ------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* N/A ---------- ------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.1% ---------- ------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IA ---------- ------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! PAGE 4 OF 9 PAGES The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative's authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature. Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Sec. 240.13d-7 for other parties for whom copies are to be sent. Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001) Item 1(a) Name of Issuer: -------------- Caliper Life Sciences Inc Item 1(b) Address of Issuer's Principal Executive Offices: ----------------------------------------------- 68 Elm Street Hopkinton, Massachusetts 01748 Item 2(a) Name of Person Filing: --------------------- This filing is made on behalf of Manulife Financial Corporation ("MFC"), and MFC's indirect, wholly-owned subsidiary, John Hancock Financial Services, Inc. ("JHFS"), JHFS's indirect, wholly-owned subsidiary, John Hancock Advisers, LLC ("JHA"). Item 2(b) Address of the Principal Offices: -------------------------------- The principal business offices of MFC are located at 200 Bloor Street, East, Toronto, Ontario, Canada, M4W 1E5. The principal business offices of JHFS are located at John Hancock Place, P.O. Box 111, Boston, MA 02117. The principal business offices of JHA are located at 101 Huntington Avenue, Boston, Massachusetts 02199. Item 2(c) Citizenship: ----------- MFC is organized and exists under the laws of Canada. JHFS and JHA were organized and exist under the laws of the State of Delaware. Item 2(d) Title of Class of Securities: ---------------------------- Common Stock Item 2(e) CUSIP Number: ------------ 896095106 Item 3 If the Statement is being filed pursuant to Rule ------------------------------------------------ 13d-1(b), or 13d-2(b), check whether the person filing is a: ----------------------------------------------------------- MFC: (g) (X) Parent Holding Company, in accordance with ss.240.13d-1(b)(ii)(G). JHFS: (g) (X) Parent Holding Company, in accordance with ss.240.13d-1(b)(ii)(G). JHLICO: (c) (X) Insurance Company as defined in ss.3(a)(19) of the Act. (e) (X) Investment Adviser registered under ss.203 of the Investment Advisers Act of 1940. PAGE 5 OF 9 PAGES (g) (X) Parent Holding Company, in accordance with ss.240.13d-1(b)(ii)(G). JHS: (g) (X) Parent Holding Company, in accordance with ss.240.13d-1(b)(ii)(G). TBFG: (g) (X) Parent Holding Company, in accordance with ss.240.13d-1(b)(ii)(G). JHA: (e) (X) Investment Adviser registered under ss.203 of the Investment Advisers Act of 1940. Item 4 Ownership: --------- (a) Amount Beneficially Owned: ------------------------- MFC has direct beneficial ownership of 605 shares of Common Stock. JHA has direct beneficial ownership of 1,832,207 shares of Common Stock. Through their parent-subsidiary relationship to JHA, MFC, JHFS have indirect, beneficial ownership of these shares held by JHA. (b) Percent of Class: MFC: 00002% ---------------- JHA: 6.1% (c) Number of shares as to which the person has: ------------------------------------------- (i) sole power to vote or to direct the vote: JHA has sole power to vote or to direct the vote of 1,832,207 shares of Common Stock under the Advisory Agreements as follows: Number Date of Advisory Fund Name of Shares Agreement --------- --------- --------- Verizon Savings Trust Small Cap Growth 209,500 December 21, 2001 John Hancock Biotechnology Fund 60,000 March 01, 2001 John Hancock Small Cap Growth Fund 1,562,707 December 02, 1996 In addition, MFC has sole power to vote or to direct the vote of 605 shares of Common Stock. (ii) shared power to vote or to direct the vote: -0- (iii) sole power to dispose or to direct the disposition of: JHA has sole power to dispose or to direct the disposition of 1,832,207 shares of Common Stock under the Advisory Agreement noted in Item 4(c)(i) above. In addition, MFC has sole power to dispose or to direct the disposition of 605 shares of Common Stock. (iv) shared power to dispose or to direct the disposition of: -0- Item 5 Ownership of Five Percent or Less of a Class: -------------------------------------------- Not applicable. Item 6 Ownership of More than Five Percent on Behalf of Another Person: --------------------------------------------------------------- See Item 4. PAGE 6 OF 9 PAGES Item 7 Identification and Classification of the Subsidiary which Acquired ------------------------------------------------------------------ the Security Being Reported on by the Parent Holding Company: ------------------------------------------------------------ See Items 3 and 4 above. Item 8 Identification and Classification of Members of the Group: --------------------------------------------------------- Not applicable. Item 9 Notice of Dissolution of a Group: -------------------------------- Not applicable. Item 10 Certification: ------------- By signing below the undersigned certifies that, to the best of its knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. PAGE 7 OF 9 PAGES SIGNATURE After reasonable inquiry and to the best of its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct. Manulife Financial Corporation By: /s/Christer V. Ahlvik ------------------------------------------------------ Name: Christer V. Ahlvik Dated: February 3, 2005 Title: Vice President and Corporate Secretary John Hancock Financial Services, Inc. By: /s/Emanuel Alves ------------------------------------------------------ Name: Emanuel Alves Dated: February 3, 2005 Title: Vice President and Corporate Secretary John Hancock Advisers, LLC By: /s/Susan S. Newton ------------------------------------------------------ Name: Susan S. Newton Dated: February 3, 2005 Title: Senior Vice President and Corporate Secretary PAGE 8 OF 9 PAGES EXHIBIT A JOINT FILING AGREEMENT ---------------------- Manulife Financial Corporation, John Hancock Financial Services, Inc., John Hancock Life Insurance Company, John Hancock Subsidiaries, LLC, The Berkeley Financial Group, LLC and John Hancock Advisers, LLC agree that the Initial Schedule 13G to which this Agreement is attached, relating to the Common Stock of Caliper Life Sciences Inc is filed on behalf of each of them. Manulife Financial Corporation By: /s/Christer V. Ahlvik ------------------------------------------------------ Name: Christer V. Ahlvik Dated: February 3, 2005 Title: Vice President and Corporate Secretary John Hancock Financial Services, Inc. By: /s/Emanuel Alves ------------------------------------------------------ Name: Emanuel Alves Dated: February 3, 2005 Title: Vice President and Corporate Secretary John Hancock Advisers, LLC By: /s/Susan S. Newton ------------------------------------------------------ Name: Susan S. Newton Dated: February 3, 2005 Title: Senior Vice President and Corporate Secretary PAGE 9 OF 9 PAGES