================================================================================

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             ----------------------

                                    FORM 10-Q

|X|  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

                  For the quarterly period ended June 30, 2009

|_|  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

                  For the transition period from       to

                             ----------------------

                        Commission File Number 000-21326

                            Anika Therapeutics, Inc.
             (Exact Name of Registrant as Specified in Its Charter)

                Massachusetts                            04-3145961
       (State or Other Jurisdiction of      (I.R.S. Employer Identification No.)
       Incorporation or Organization)

  32 Wiggins Avenue, Bedford, Massachusetts                 01730
  (Address of Principal Executive Offices)               (Zip Code)

       Registrant's Telephone Number, Including Area Code: (781) 457-9000

               Former Name, Former Address and Former Fiscal Year,
                       if Changed Since Last Report: N/A

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the last 90 days. Yes |X| No |_|

         Indicate by check mark whether the registrant has submitted
electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation
S-T (ss.232.405 of this chapter) during the preceding 12 months (or for such
shorter period that the registrant was required to submit and post such files).
|_| Yes |_| No

         Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or a smaller reporting
company. See the definitions of "large accelerated filer," "accelerated filer"
and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check One):

Large accelerated filer |_|   Accelerated filer |X|   Non-accelerated filer |_|
Smaller reporting company |_|                        (Do not check if a smaller
                                                         reporting company)

         Indicate by checkmark whether the registrant is a shell company (as
defined in Rule 12b-2 of the Exchange Act). Yes |_| No |X|

         As of July 31, 2009, there were 11,437,981 outstanding shares of Common
Stock, par value $.01 per share.

================================================================================




PART I: FINANCIAL INFORMATION
ITEM 1: FINANCIAL STATEMENTS

                     Anika Therapeutics, Inc. and Subsidiary
                           Consolidated Balance Sheets
                                   (unaudited)

                                                        June 30,    December 31,
                                                          2009          2008
                                                      ------------  ------------
                       ASSETS
Current assets:
 Cash and cash equivalents                           $ 39,549,558  $ 43,193,655
 Accounts receivable, net                               6,456,273     5,418,421
 Inventories                                            7,304,711     5,519,754
 Current portion deferred income taxes                  1,235,364     1,235,364
 Prepaid expenses and other                               505,054       463,284
                                                      ------------  ------------
   Total current assets                                55,050,960    55,830,478
Property and equipment, at cost                        44,175,496    42,436,827
Less: accumulated depreciation                        (10,829,226)  (10,190,144)
                                                      ------------  ------------
                                                       33,346,270    32,246,683
Long-term deposits and other                              351,477       506,787
Intangible asset, net                                     906,863       936,275
Deferred income taxes                                   6,302,507     6,300,665
                                                      ------------  ------------
Total Assets                                         $ 95,958,077  $ 95,820,888
                                                      ============  ============

        LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
 Accounts payable                                    $  1,769,194  $  2,375,340
 Accrued expenses                                       3,151,745     2,325,219
 Deferred revenue                                       2,756,330     2,732,293
 Current portion of long-term debt                      1,600,000     1,600,000
 Income taxes payable                                     208,811            --
                                                      ------------  ------------
   Total current liabilities                            9,486,080     9,032,852
Other long-term liabilities                               879,669       831,051
Long-term deferred revenue                              9,449,996    10,800,001
Long-term debt                                         13,600,000    14,400,000
Commitments and contingencies (Notes 9 and 12)
Stockholders' equity
 Preferred stock, $.01 par value; 1,250,000 shares
  authorized, no shares issued and outstanding                 --            --
 Common stock, $.01 par value; 30,000,000 shares
  authorized, 11,437,981 and 11,377,623 shares issued
  and outstanding at June 30, 2009 and December 31,
  2008, respectively                                      114,380       113,776
 Additional paid-in-capital                            43,167,479    42,861,229
 Retained earnings                                     19,260,473    17,781,979
                                                      ------------  ------------
   Total stockholders' equity                          62,542,332    60,756,984
                                                      ------------  ------------
Total Liabilities and Stockholders' Equity           $ 95,958,077  $ 95,820,888
                                                      ============  ============

  The accompanying notes are an integral part of these unaudited consolidated
                             financial statements.





                               Anika Therapeutics, Inc. and Subsidiary
                                Consolidated Statements of Operations
                                           (unaudited)

                                                     Three Months Ended June 30,  Six Months Ended June 30,
                                                     --------------------------- ---------------------------
                                                          2009          2008          2009          2008
                                                     ------------- ------------- ------------- -------------
                                                                                   
Product revenue                                      $  8,770,763  $  8,378,936  $ 17,289,836  $ 16,246,465
Licensing, milestone and contract revenue                 752,913       681,253     1,434,164     1,362,503
                                                     ------------- ------------- ------------- -------------
  Total revenue                                         9,523,676     9,060,189    18,724,000    17,608,968

Operating expenses:
 Cost of product revenue                                3,294,160     3,644,530     6,505,826     6,860,600
 Research & development                                 2,286,229     1,644,619     4,480,537     3,152,959
 Selling, general & administrative                      2,735,552     2,880,156     5,770,534     5,948,772
                                                     ------------- ------------- ------------- -------------
Total operating expenses                                8,315,941     8,169,305    16,756,897    15,962,331
                                                     ------------- ------------- ------------- -------------
Income from operations                                  1,207,735       890,884     1,967,103     1,646,637
  Interest income (expense), net                           (1,382)      157,875            58       347,281
                                                     ------------- ------------- ------------- -------------
Income before income taxes                              1,206,353     1,048,759     1,967,161     1,993,918
  Provision for income taxes                              250,579       235,830       488,667       563,431
                                                     ------------- ------------- ------------- -------------
Net income                                           $    955,774  $    812,929  $  1,478,494  $  1,430,487
                                                     ============= ============= ============= =============
Basic net income per share:
  Net income                                         $       0.08  $       0.07  $       0.13  $       0.13
  Basic weighted average common shares outstanding     11,384,949    11,327,457    11,375,798    11,276,871
Diluted net income per share:
  Net income                                         $       0.08  $       0.07  $       0.13  $       0.12
  Diluted weighted average common shares outstanding   11,548,079    11,516,177    11,517,949    11,502,720


  The accompanying notes are an integral part of these unaudited consolidated
                             financial statements.





                     Anika Therapeutics, Inc. and Subsidiary
                      Consolidated Statements of Cash Flows
                            For the Six Months Ended
                                   (unaudited)

                                                           June 30,       June 30,
                                                             2009           2008
                                                        --------------  --------------
                                                                  
Cash flows from operating activities:
 Net income                                             $   1,478,494   $   1,430,487
 Adjustments to reconcile net income to net cash
  provided by (used in) operating activities:
   Depreciation and amortization                              668,495         739,940
   Amortization of premium on short-term investment                --           1,974
   Stock-based compensation expense                           454,956         704,434
   Deferred income taxes                                     (157,269)       (236,281)
   Provision for inventory reserve                            169,708          22,434
   Tax benefit from exercise of stock options                  (4,175)       (229,920)
   Changes in operating assets and liabilities:
     Accounts receivable                                   (1,037,852)       (136,113)
     Inventories                                           (1,954,666)       (414,796)
     Prepaid expenses, other current and long-term
      assets                                                  113,540         609,673
     Accounts payable and accrued expenses                  1,047,515        (794,132)
     Deferred revenue                                      (1,325,968)     (1,337,504)
     Income taxes payable                                     212,986         317,503
     Other long-term liabilities                               48,618         203,920
                                                        --------------  --------------
Net cash provided by (used in) operating activities          (285,618)        881,619
                                                        --------------  --------------

Cash flows from investing activities:
 Proceeds from maturity of short-term investment                   --       3,500,000
 Purchase of property and equipment, net                   (2,565,804)    (11,606,719)
                                                        --------------  --------------
Net cash used in investing activities                      (2,565,804)     (8,106,719)
                                                        --------------  --------------

Cash flows from financing activities:
 Proceeds from long-term debt                                      --       8,000,000
 Principal payments on debt                                  (800,000)             --
 Debt issuance costs                                               --         (87,721)
 Proceeds from exercise of stock options                        3,150         476,811
 Tax benefit from exercise of stock options                     4,175         229,920
                                                        --------------  --------------
Net cash provided by (used in) financing activities          (792,675)      8,619,010
                                                        --------------  --------------

Increase (decrease) in cash and cash equivalents           (3,644,097)      1,393,910
Cash and cash equivalents at beginning of year             43,193,655      35,903,569
                                                        --------------  --------------
Cash and cash equivalents at end of period              $  39,549,558   $  37,297,479
                                                        ==============  ==============

Supplemental disclosure of cash flow information:
  Cash paid for income taxes                            $     320,000   $      10,000
                                                        --------------  --------------
  Interest paid for debt                                $     126,328   $          --
                                                        --------------  --------------


  The accompanying notes are an integral part of these unaudited consolidated
                             financial statements.



                            ANIKA THERAPEUTICS, INC.
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                   (Unaudited)

1.   Nature of Business

         Anika Therapeutics, Inc. ("Anika," the "Company," "we," "us," or "our")
develops, manufactures and commercializes therapeutic products for tissue
protection, healing, and repair. These products are based on hyaluronic acid
("HA"), a naturally occurring, biocompatible polymer found throughout the body.
Due to its unique biophysical and biochemical properties, HA plays an important
role in a number of physiological functions such as the protection and
lubrication of soft tissues and joints, the maintenance of the structural
integrity of tissues, and the transport of molecules to and within cells. The
Company's currently manufactured and marketed products consist of ORTHOVISC(R),
which is an HA product used in the treatment of some forms of osteoarthritis in
humans; AMVISC(R), AMVISC(R) Plus, STAARVISC(TM)-II, and ShellGel(TM), each an
injectable ophthalmic viscoelastic HA product; HYVISC(R), which is an HA product
used in the treatment of equine osteoarthritis, and INCERT(R), which is an HA
based anti-adhesive for surgical applications. ORTHOVISC(R) mini, a treatment
for osteoarthritis targeting small joints is available in Europe. MONOVISC(TM),
a single-injection osteoarthritis product based on our proprietary cross-linking
technology is available in Europe and Turkey. In the U.S. and several countries
in Latin America, ORTHOVISC(R) is marketed by DePuy Mitek, Inc., a subsidiary of
Johnson & Johnson, under the terms of a licensing, distribution, supply and
marketing agreement. Outside the U.S., ORTHOVISC(R) has been approved for sale
since 1996 and is marketed by distributors in approximately 20 countries. We
developed and manufacture AMVISC(R) and AMVISC(R) Plus for Bausch & Lomb
Incorporated under a multiyear supply agreement. We also produce
STAARVISC(TM)-II, which is distributed by STAAR Surgical Company and
Shellgel(TM) for Cytosol Ophthalmics, Inc. HYVISC(R) is marketed in the U.S.
through Boehringer Ingelheim Vetmedica, Inc. INCERT(R) is currently marketed in
three countries outside of the U.S. Our aesthetic dermatology business is
designed to have a family of products for facial wrinkles and scar remediation.
Our initial aesthetic dermatology product is approved in the U.S., European
Union (EU), Canada and certain countries in South America. This product is
marketed in the U.S. by CoApt Systems, Inc. under the name of HYDRELLE(TM).
Internationally, this product is marketed under the ELEVESS(TM) name. Products
in development include a next generation HYDRELLE/ELEVESS(TM) line extension,
and joint health related products.

         The Company is subject to risks common to companies in the
biotechnology and medical device industries including, but not limited to,
development by the Company or its competitors of new technological innovations,
dependence on key personnel, protection of proprietary technology,
commercialization of existing and new products, and compliance with the U.S.
Food and Drug Administration ("FDA") government regulations and approval
requirements as well as the ability to grow the Company's business.

2.   Basis of Presentation

         The accompanying consolidated financial statements have been prepared
by the Company without audit, pursuant to the rules and regulations of the
Securities and Exchange Commission (the "SEC") and in accordance with accounting
principles generally accepted in the United States. In the opinion of
management, these consolidated financial statements contain all adjustments
(consisting only of normal recurring adjustments) necessary to fairly state the
financial position of the Company as of June 30, 2009 and the results of its
operations and cash flows for the three and six months ended June 30, 2009 and
2008.

         Effective January 1, 2009 the Company adopted the Financial Accounting
Standards Board Staff Position ("FSP") Emerging Issues Task Force ("EITF") Issue
03-6-1, "Determining Whether Instruments Granted in Share-Based Payment
Transactions Are Participating Securities." The retroactive adoption of this
pronouncement did not have a material impact on basic and diluted earnings per
share for the three and six months ended June 30, 2008. See Note 6 for
additional disclosures.

         The accompanying consolidated financial statements and related notes
should be read in conjunction with the Company's annual financial statements
filed with its Annual Report on Form 10-K for the year ended December 31, 2008.
The results of operations for the three and six months ended June 30, 2009 are
not necessarily indicative of the results to be expected for the year ending
December 31, 2009, or any future periods.

3.   Summary of Significant Accounting Policies

Use of Estimates

         The preparation of financial statements in conformity with generally
accepted accounting principles in the United States of America requires
management to make estimates and assumptions that affect the reported amounts of
assets and liabilities and disclosure of contingent assets and liabilities at
the date of the financial statements and the reported amounts of revenues and
expenses during the reporting period. Actual results could differ from those
estimates.



Principles of Consolidation

         The accompanying consolidated financial statements include the accounts
of Anika Therapeutics, Inc. and its wholly owned subsidiary, Anika Securities,
Inc. (a Massachusetts Securities Corporation). All intercompany balances and
transactions have been eliminated in consolidation.

Subsequent Events

         Effective this quarter, the Company implemented Statement of Financial
Accounting Standards No. 165, "Subsequent Events" ("SFAS 165"). This standard
establishes general standards of accounting for and disclosure of events that
occur after the balance sheet date but before financial statements are issued.
The adoption of SFAS 165 did not impact our financial position or results of
operations. We evaluated all significant events or transactions that occurred
through August 5, 2009, the date we issued these financial statements. During
this period, we did not have any material recognizable subsequent events.

Cash, Cash Equivalents and Short-term Investments

         Cash and cash equivalents consist of cash and highly liquid investments
with original maturities of 90 days or less. The Company accounts for short-term
investments in accordance with the Statement of Financial Accounting Standards
("SFAS") No. 115, "Accounting for Certain Investments in Debt and Equity
Securities." The Company determines the appropriate classification of all
short-term investments as held-to-maturity, available-for-sale or trading at the
time of purchase and re-evaluates such classifications as of each balance sheet
date. At June 30, 2009 and December 31, 2008, cash equivalents consisted of
money market funds invested in U.S. Treasury obligations and repurchase
agreements secured by U.S. Treasury obligations, which approximates fair market
value.

Fair Value Measurements

         SFAS No. 157 establishes a three-level hierarchy which prioritizes the
inputs used in measuring fair value. In general, fair value determined by Level
1 inputs utilize quoted prices in active markets for identical assets or
liabilities. Fair values determined by Level 2 inputs utilize data points that
are observable such as quoted prices, interest rates and yield curves. Fair
values determined by Level 3 inputs are unobservable data points for the asset
or liability, and includes situations where there is little, if any, market
activity for the asset or liability. The fair value of our cash equivalents were
$34,201,711 and $34,197,953 at June 30, 2009 and December 31, 2008,
respectively, based on Level 1 inputs. Effective January 1, 2009, the Company
adopted the provisions under SFAS No. 157 for valuation of nonfinancial assets
and nonfinancial liabilities. The adoption of such provisions did not impact the
Company's financial position, results of operations, or cash flows.

         Effective this quarter, the Company also implemented FSP FAS 107-1 and
Accounting Principles Board ("APB") 28-1, "Interim Disclosures about Fair Value
of Financial Instruments" ("FSP FAS 107-1"). FSP FAS 107-1 amended SFAS No. 107,
Disclosures about Fair Value of Financial Instruments, and APB Opinion No. 28,
Interim Financial Reporting, to require disclosures about the fair value of
financial instruments in interim as well as in annual financial statements. The
adoption of this standard has resulted in the disclosure of the fair value of
the Company's long term debt instrument on a quarterly basis. Since FSP FAS
107-1 addresses disclosure requirements, the adoption of this FSP did not impact
our financial position or results of operations. The carrying value of our debt
instrument was $15,200,000 at June 30, 2009. The estimated fair value of our
debt instrument was approximately $14,400,000 at June 30, 2009. The fair value
was estimated using market observable inputs and interest rate measurements.

Revenue Recognition

         The Company's revenue recognition policies are in accordance with the
SEC Staff Accounting Bulletin No. 101, "Revenue Recognition in Financial
Statements," as amended by SEC Staff Accounting Bulletin No. 104, "Revenue
Recognition," Emerging Issues Task Force Issue No. 00-21, "Revenue Arrangements
with Multiple Deliverables," and EITF 07-1 "Accounting for Collaborative
Arrangements," which became effective on January 1, 2009. Adoption of EITF 07-1
did not impact our financial statements for the three and six month periods
ended June 30, 2009 and 2008.

     Product Revenue

         The Company recognizes revenue from the sales of products it
manufactures upon confirmation of regulatory compliance and shipment to the
customer as long as there is (1) persuasive evidence of an arrangement, (2)
delivery has occurred and risk of loss has passed, (3) the sales price is fixed
or determinable and (4) collection of the related receivable is reasonably
assured. Amounts billed or collected prior to recognition of revenue are
classified as deferred revenue. When determining whether risk of loss has
transferred to customers on product sales or if the sales price is fixed or
determinable, the Company evaluates both the contractual terms and conditions of
its distribution and supply agreements as well as its business practices.



Product revenue also includes royalties. Royalty revenue is based on our
distributor's sales and recognized in the same period that our distributor
records their sale of the product.

     License, Milestone and Contract Revenue

         License, milestone and contract revenue consists of revenue recognized
on initial and milestone payments as well as other contractual amounts received
from partners. The Company's business strategy includes entering into
collaborative license, development and/or supply agreements with partners for
the development and commercialization of the Company's products. The terms of
the agreements typically include non-refundable license fees, funding of
research and development, payments based upon achievement of certain milestones
and royalties on product sales. The Company evaluates each agreement and
elements within each agreement in accordance with EITF 00-21. Under EITF 00-21,
in order to account for an element as a separate unit of accounting, the element
must have stand-alone value and there must be objective and reliable evidence of
fair value of the undelivered elements. In general, non-refundable upfront fees
and milestone payments are recognized as revenue over the term of the
arrangement as the Company completes its performance obligations. For
collaborative arrangements, the Company reports on a gross basis if it acts as a
principal under the arrangements. Any payments received from (made to) other
collaborators are accounted for based on existing applicable generally accepted
accounting principles ("GAAP") or, in the absence of other applicable GAAP,
based on analogous authoritative accounting literature, or a reasonable,
rational, and consistently applied accounting policy election.

Accounts Receivable and Allowance for Doubtful Accounts

         Trade accounts receivable are recorded at the invoiced amount and do
not bear interest. The allowance for doubtful accounts is the Company's best
estimate of the amount of probable credit losses in its existing accounts
receivable. The Company determines the allowance based on specific
identification. The Company reviews its allowance for doubtful accounts at least
quarterly. Account balances are charged-off against the allowance when the
Company feels it is probable the receivable will not be recovered. Allowance for
doubtful accounts was $87,000 and $60,000 at June 30, 2009 and December 31,
2008, respectively.

Long Lived Assets

         The Company accounts for impairment of long-lived assets in accordance
with SFAS No. 144, "Accounting for the Impairment or Disposal of Long-Lived
Assets" ("SFAS No. 144"). SFAS No. 144 establishes a uniform accounting model
for long-lived assets to be disposed of. This Statement also requires that
long-lived assets be reviewed for impairment whenever events or changes in
circumstances indicate that the carrying amount of an asset may not be
recoverable. Recoverability of assets to be held and used is measured by
comparing the carrying amount of an asset to estimated undiscounted future net
cash flows expected to be generated by the asset. If the carrying amount of the
asset exceeds its estimated future cash flows, an impairment charge is
recognized in the amount by which the carrying amount of the asset exceeds the
fair value of the asset. As of June 30, 2009, long-lived assets consisted of
machinery, equipment, leasehold improvements and an intangible asset. The
Company's intangible asset consists of its ELEVESS trade name. During the second
quarter of 2009, the Company signed an exclusive distribution agreement with
CoApt Systems, Inc. ("CoApt") for the distribution in the United States of
Anika's aesthetic dermatology products for facial wrinkles. CoApt is marketing
the Company's existing product under the name HYDRELLE(TM), which caused the
Company to perform a recoverability test in accordance with SFAS No. 144
requirements in order to determine if the carrying value for the ELEVESS trade
name was impaired. Our existing aesthetic dermatology product continues to be
marketed outside of the U.S. under the ELEVESS(TM) name. The analysis concluded
that the undiscounted cash flow exceeds the carrying value of the ELEVESS asset
group. Significant assumptions underlying the recoverability of the intangible
asset include: future cash flow, growth projections, product life cycle and
useful life assumptions. The ultimate recoverability of the asset is dependent
on the Company securing additional distributors. Recoverability of the carrying
value of the asset may also be impacted by the outcome of the pending trade name
opposition (Note 11). Changes in these assumptions could materially impact the
Company's ability to realize the value of its intangible asset.

         Effective January 1, 2009, the Company adopted FSP No. 142-3,
"Determination of the Useful Life of Intangible Assets." This FSP amends the
factors that should be considered in developing renewal or extension assumptions
used to determine the useful life of a recognized intangible asset under SFAS
No. 142, "Goodwill and Other Intangible Assets." The adoption did not have an
impact on our financial position and results of operations for the three and six
months ended June 30, 2009.

         Property and equipment are carried at cost less accumulated
depreciation, subject to review for impairment whenever events or changes in
circumstances indicate that the carrying amount of the asset may not be
recoverable. Costs of major additions and improvements are capitalized;
maintenance and repairs that do not improve or extend the life of the respective



assets are charged to operations. On disposal, the related accumulated
depreciation or amortization is removed from the accounts and any resulting gain
or loss is included in results of operations. Depreciation is computed using the
straight-line method over the estimated useful lives of the assets. Leasehold
improvements are amortized over the lesser of the useful life or the expected
term of the respective lease. Machinery and equipment are depreciated from 5 to
10 years, furniture and fixtures from 5 to 7 years and computer software and
hardware from 3 to 5 years. Interest costs incurred during the construction of
major capital projects are capitalized in accordance with SFAS No. 34,
"Capitalization of Interest Costs" ("SFAS 34"). The interest is capitalized
until the underlying asset is ready for its intended use, at which point the
interest cost is amortized as interest expense over the life of the underlying
assets. We capitalize certain direct and incremental costs associated with the
validation effort related to FDA approval of our manufacturing facility and
equipment for the production of our commercial products. These costs include
construction costs, equipment costs, direct labor and materials incurred in
preparing the facility and equipment for their intended use. The validation
costs are amortized over the estimated useful life of the related facility and
equipment.

Stock-Based Compensation

         The Company accounts for stock-based compensation under the provisions
of SFAS No. 123R, ("SFAS 123R"), "Share-Based Payment," which establishes
accounting for equity instruments exchanged for employee services. Under the
provisions of SFAS No. 123R, share-based compensation cost is measured at the
grant date, based on the calculated fair value of the award, and is recognized
as an expense over the employee's requisite service period (generally the
vesting period of the equity grant). For awards with a performance condition
vesting feature, when achievement of the performance condition is deemed
probable, the Company recognizes compensation cost on a graded-vesting basis
over the awards' expected vesting periods. The Company assesses probability on a
quarterly basis. See Note 5 for additional disclosures.

Disclosures About Segments of an Enterprise and Related Information

         Operating segments are identified as components of an enterprise about
which separate discrete financial information is available for evaluation by the
chief operating decision maker, or decision-making group, in making decisions
regarding how to allocate resources and assess performance. The Company's chief
operating decision maker is its Chief Executive Officer. Based on the criteria
established by SFAS No. 131, "Disclosures about Segments of an Enterprise and
Related Information," the Company has one reportable operating segment, the
results of which are disclosed in the accompanying consolidated financial
statements. All of the operations and assets of the Company have been derived
from and are located in the United States.

         Product revenue by product group is as follows:


                Three Months Ended June 30,     Six Months Ended June 30,
                ----------------------------  ----------------------------
                     2009           2008           2009           2008
                -------------  -------------  -------------  -------------
Joint Health    $  5,568,685   $  4,765,474   $ 10,718,327   $  8,887,654
Ophthalmic         2,480,923      2,562,218      5,126,175      5,580,889
Veterinary           611,600      1,020,394      1,248,935      1,721,017
Aesthetics            88,080         13,050        138,174         16,050
Other                 21,475         17,800         58,225         40,855
                -------------  -------------  -------------  -------------
                $  8,770,763   $  8,378,936   $ 17,289,836   $ 16,246,465
                =============  =============  =============  =============


         Product revenue by significant customers as a percentage of total
product revenue is as follows:


                               Percent of Product Revenue  Percent of Product Revenue

                               Three Months Ended June 30, Six Months Ended June 30,
                               --------------------------- --------------------------
                                    2009          2008         2009          2008
                               -------------  ------------ ------------  ------------
                                                                    
Depuy Mitek                            46.7%         38.1%        44.9%         39.9%
Bausch & Lomb Incorporated             27.2%         28.4%        28.1%         31.8%
Boehringer Ingelheim Vetmedica          7.0%         12.2%         7.2%         10.6%
Biomeks                                 5.6%          8.1%         5.6%          4.2%
                               -------------  ------------ ------------  ------------
                                       86.5%         86.8%        85.8%         86.5%
                               =============  ============ ============  ============




         As of June 30, 2009, five customers represented 92% of the Company's
accounts receivable balance, and as of December 31, 2008, five customers
represented 90% of the Company's accounts receivable balance.

         Product revenue by geographic location in total and as a percentage of
total product revenue, for the three and six months ended June 30, 2009 and 2008
are as follows:

                                     Three Months Ended June 30,
                      ----------------------------------------------------------
                                  2009                          2008
                      -----------------------------  ---------------------------
                                       Percent of                    Percent of
                          Revenue       Revenue        Revenue        Revenue
                      --------------- -------------  ------------  -------------
Geographic location:
United States         $     6,461,662         73.7%  $  5,963,233          71.2%
Europe                      1,322,041         15.0%     1,248,905          14.9%
Other                         987,060         11.3%     1,166,798          13.9%
                      --------------- -------------  ------------  -------------
  Total               $     8,770,763        100.0%  $  8,378,936         100.0%
                      =============== =============  ============  =============

                                      Six Months Ended June 30,
                      ----------------------------------------------------------
                                 2009                         2008
                      -----------------------------  ---------------------------
                                       Percent of                    Percent of
                         Revenue         Revenue        Revenue       Revenue
                      --------------- -------------  ------------  -------------
Geographic location:
United States         $    12,597,226         72.9%  $ 12,117,344          74.6%
Europe                      2,805,409         16.2%     2,571,198          15.8%
Other                       1,887,201         10.9%     1,557,923           9.6%
                      --------------- -------------  ------------  -------------
  Total               $    17,289,836        100.0%  $ 16,246,465         100.0%
                      =============== =============  ============  =============

Income Taxes

         The Company accounts for uncertain income tax positions using a benefit
recognition model with a two-step approach, a more-likely-than-not recognition
criterion and a measurement attribute that measures the position as the largest
amount of tax benefit that is greater than 50% likely of being realized upon
ultimate settlement in accordance with FASB Interpretation No. 48, "Accounting
for Uncertainty in Income Taxes, an Interpretation of FASB Statement No. 109"
("FIN 48"). If it is not more likely than not that the benefit will be sustained
on its technical merits, no benefit will be recorded. Uncertain tax positions
that relate only to timing of when an item is included on a tax return are
considered to have met the recognition threshold. It is the Company's policy to
classify accrued interest and penalties as part of the accrued FIN 48 liability
and record the expense in the provision for income taxes.

         We record a deferred tax asset or liability based on the difference
between the financial statement and tax basis of assets and liabilities, as
measured by the enacted tax rates assumed to be in effect when these differences
reverse. As of June 30, 2009, management determined that it is more likely than
not that the deferred tax assets will be realized and, therefore, a valuation
allowance has not been recorded.

Recent Accounting Pronouncements

         On January 1, 2009, the Company adopted the provisions of SFAS No.
141(R), "Business Combinations" ("SFAS No. 141(R)"), which revised SFAS No. 141,
"Business Combinations." The statement retains the purchase method of accounting
for acquisitions, but requires a number of changes, including changes in the way
assets and liabilities are recognized in the purchase accounting. It also
changes the recognition of assets acquired and liabilities assumed arising from
contingencies, requires the capitalization of in-process research and
development at fair value, and requires the expensing of acquisition-related
costs as incurred. The adoption did not have a material impact on the Company's
financial statements.

         On June 3, 2009, the FASB approved the FASB Accounting Standards
Codification, or the Codification, as the single source of authoritative
nongovernmental Generally Accepted Accounting Principles, or GAAP, in the United
States. The Codification will be effective for interim and annual periods ending
after September 15, 2009. Upon the effective date, the Codification will be the



single source of authoritative accounting principles to be applied by all
nongovernmental U.S. entities. All other accounting literature not included in
the Codification will be nonauthoritative. We do not expect the adoption of the
Codification to have an impact on our financial position or results of
operations.

         Disclosures of additional new accounting pronouncements adopted during
the first six months of 2009 are discussed in Notes 3 and 6.

4.   Short-term Investment

         In February 2007, the Company purchased a tax exempt municipal bond for
a cost of $3,526,985 with a par value of $3,500,000 and an interest rate of
4.25%. This investment matured on February 1, 2008. The Company classifies its
investments in debt and equity securities into held-to-maturity,
available-for-sale or trading categories in accordance with the provisions of
SFAS No. 115, "Accounting For Certain Investments in Debt and Equity
Securities." The tax exempt municipal bond was classified as held-to-maturity in
2007 because the Company intended, and held the security to maturity.
Held-to-maturity securities are stated at amortized cost.

5.   Stock-Based Compensation

         The Company estimates the fair value of stock options and stock
appreciation rights using the Black-Scholes valuation model. Fair value of
restricted stock is measured by the grant-date price of the Company's shares.
The fair value of each stock option and stock appreciation rights award during
the three and six months ended June 30, 2009 and 2008 was estimated on the grant
date using the Black-Scholes option-pricing model with the following
assumptions:

                                        Three Months Ended
                           ---------------------------------------------
                               June 30, 2009          June 30, 2008
                           ---------------------  ----------------------
  Risk-free interest rate          1.85%              2.39% - 2.82%
  Expected volatility             59.35%             58.15% - 63.37%
  Expected lives (years)             4                     3-4
  Expected dividend yield          0.00%                  0.00%

                                         Six Months Ended
                           ---------------------------------------------
                               June 30, 2009          June 30, 2008
                           ---------------------  ----------------------
  Risk-free interest rate      1.54% - 1.85%          2.39% - 2.82%
  Expected volatility         59.35% - 59.39%        58.15% - 63.37%
  Expected lives (years)             4                     3-4
  Expected dividend yield          0.00%                  0.00%

         The Company recorded $254,599 and $454,956 of share-based compensation
expense for the three and six months ended June 30, 2009, respectively, for
equity compensation awards. The Company recorded $381,145 and $704,434 of
share-based compensation expense for the three and six months ended June 30,
2008, respectively, for equity compensation awards. The Company presents the
expenses related to stock-based compensation awards in the same expense line
items as cash compensation paid to the same employees.

Stock Option Plan

         The Company has reserved 1,500,000 shares of common stock for grants to
employees, directors, consultants and advisors under the 2003 Plan, which was
approved by stockholders on June 4, 2003. On May 29, 2009, the Board of
Directors approved the Company's Amended and Restated 2003 Stock Option and
Incentive Plan, the ("2003 Plan"), to increase the number of shares subject to
the 2003 Plan by 850,000, which was approved by the Company's shareholders on
June 5, 2009. This resulted in a total of 2,350,000 shares of common stock being
reserved for issuance under the 2003 Plan. The Company issues new shares upon
share option exercises from its authorized shares. Stock-based awards are
granted with an exercise price equal to the market price of the Company's stock
on the date of grant. The Company's stock-based awards contain service or
performance conditions. Awards generally vest annually over 3 to 4 years. Awards
have 10-year contractual terms.



6.   Earnings Per Share

         The Company reports earnings per share in accordance with SFAS No. 128,
"Earnings per Share," which establishes standards for computing and presenting
earnings per share. Basic earnings per share is computed by dividing net income
by the weighted average number of common shares outstanding during the period.
Diluted earnings per share is computed by dividing net income by the weighted
average number of common shares outstanding and the number of dilutive potential
common share equivalents during the period. Under the treasury stock method,
unexercised "in-the-money" stock options are assumed to be exercised at the
beginning of the period or at issuance, if later. The assumed proceeds are then
used to purchase common shares at the average market price during the period.

         Effective January 1, 2009 the Company adopted FSP EITF Issue 03-6-1,
"Determining Whether Instruments Granted in Share-Based Payment Transactions Are
Participating Securities" ("FSP EITF 03-6-1"). FSP EITF 03-6-1 clarifies that
share-based payment awards that entitle their holders to receive non-forfeitable
dividends before vesting should be considered participating securities. As
participating securities, these instruments are included in the calculation of
basic and diluted earnings per shares. Adoption of this pronouncement is
retroactive to prior reporting periods. Basic and diluted earnings per share for
the three and six months ended June 30, 2009 and 2008 are as follows:


                                                   Three Months Ended         Six Months Ended
                                                         June 30,                  June 30,
                                                     2009         2008         2009         2008
                                                 ------------ ------------ ------------ ------------
                                                                            
Basic earnings per share
Net income                                       $   955,774  $   812,929  $ 1,478,494  $ 1,430,487
Income allocated to participating securities          (4,315)      (7,889)      (4,925)     (11,924)
                                                 ------------ ------------ ------------ ------------
Income available to common stockholders              951,459      805,040    1,473,569    1,418,563
Basic weighted average common shares outstanding  11,384,949   11,327,457   11,375,798   11,276,871
Basic earnings per share                         $      0.08  $      0.07  $      0.13  $      0.13

Diluted earnings per share
Net income                                       $   955,774  $   812,929  $ 1,478,494  $ 1,430,487
Income allocated to participating securities          (4,256)      (7,761)      (4,865)     (11,692)
                                                 ------------ ------------ ------------ ------------
Income available to common stockholders              951,518      805,168    1,473,629    1,418,795
Weighted average common shares outstanding        11,384,949   11,327,457   11,375,798   11,276,871
Diluted potential common shares                      163,130      188,720      142,151      225,849
Diluted weighted average common shares and
 potential common shares                          11,548,079   11,516,177   11,517,949   11,502,720
Diluted earnings per share                       $      0.08  $      0.07  $      0.13  $      0.12


         Equity awards of 930,947 shares were outstanding for the three and six
months ended June 30, 2009, respectively, but not included in the computation of
diluted earnings per share because the awards' impact on earnings per share was
anti-dilutive. Equity awards of 554,077 and 548,885 shares were outstanding for
the three and six months ended June 30, 2008, respectively, but not included in
the computation of diluted earnings per share because the awards' impact on
earnings per share was anti-dilutive.

7.   Inventories

         Inventories consist of the following:


                                        June 30,      December 31,
                                          2009            2008
                                     --------------  ---------------
          Raw materials              $   2,997,118    $   2,556,588
          Work-in-process                2,743,394        2,354,736
          Finished goods                 1,564,199          608,430
                                     --------------  ---------------
           Total                     $   7,304,711    $   5,519,754
                                     ==============  ===============


         Inventories are stated at the lower of cost or market, with cost being
determined using the first-in, first-out (FIFO) method. Work-in-process and
finished goods inventories include materials, labor, and manufacturing overhead.
Inventories increased from December 31, 2008 due to the planned inventory build
up in preparation for moving some equipment to our Bedford manufacturing
facility.

8.   Accrued Expenses

         Accrued expenses consist of the following:

                                        June 30,      December 31,
                                          2009            2008
                                     --------------  ---------------
           Payroll and benefits      $   1,433,817   $    1,380,901
           Clinical trial costs            762,889          285,500
           Professional fees               413,267          332,570
           Other                           541,772          326,248
                                     --------------  ---------------
            Total                    $   3,151,745   $    2,325,219
                                     ==============  ===============


9.   Guarantor Arrangements

         In certain of its contracts, the Company warrants to its customers that
the products it manufactures conform to the product specifications as in effect
at the time of delivery of the product. The Company may also warrant that the
products it manufactures do not infringe, violate or breach any patent or
intellectual property rights, trade secret or other proprietary information of
any third party. On occasion, the Company contractually indemnifies its
customers against any and all losses arising out of or in any way connected with
any claim or claims of breach of its warranties or any actual or alleged defect
in any product caused by the negligence or acts or omissions of the Company. The
Company maintains a products liability insurance policy that limits its
exposure. Based on the Company's historical activity in combination with its
insurance policy coverage, the Company believes the estimated fair value of
these indemnification agreements is minimal. The Company has no accrued
warranties and has no history of claims paid.

10.  Long-term Debt

         On January 31, 2008, the Company entered into an unsecured Credit
Agreement (the "Agreement") with Bank of America, under which the Company was
provided with a revolving credit line through December 31, 2008 of up to a
maximum principal amount at any time outstanding of $16,000,000. The Company
recorded approximately $171,000 as deferred issuance costs, which is being
amortized over the life of the long-term debt. The Company borrowed the maximum
amount of $16,000,000 in 2008 to finance its new facility construction and
validation capital project. On December 31, 2008, in accordance with the
Agreement, the outstanding revolving credit loans were converted into a term
loan with quarterly principal payments of $400,000 and a final installment of
$5,200,000 due on the maturity date of December 31, 2015. Long-term debt
principal payments over the next five years are $1,600,000 per year.

         The Company made two quarterly principal payments of $400,000 on March
31, 2009 and June 30, 2009, respectively. The interest payable on our debt is
determined based on either an interest rate based on LIBOR plus 0.75% or the
lender's prime rate. As of June 30, 2009, the Company had an outstanding debt
balance of $15,200,000, at an interest rate of 1.05%. The Company capitalized
interest expense of $28,044 and $98,183 for the three and six months ended June
30, 2009, respectively, as part of construction in progress related to the
Company's new facility build-out in accordance with SFAS No. 34, "Capitalization
of Interest Costs."



11.  Income Taxes

         Income tax expense was $250,579 and $235,830 for the three months ended
June 30, 2009 and 2008, respectively. Income tax expense was $488,667 and
$563,431 for the six months ended June 30, 2009 and 2008, respectively. The
effective tax rates were 20.8% and 22.5% for the three months ended June 30,
2009 and 2008, respectively. The effective tax rates were 24.8% and 28.3% for
the six months ended June 30, 2009 and 2008, respectively. The decrease in
effective tax rate was primarily due to increases in research tax credits.
During the first six months of 2009, there was no change to the Company's FIN 48
tax reserves. Our U.S. federal income tax returns for the years 2005, 2006, and
2007 remain subject to examination, and our state income tax returns for the
years 2006 and 2007 remain subject to examination.

12.  Trademark Opposition

         On December 12, 2007, Colbar Lifescience Ltd. ("Colbar"), a subsidiary
of Johnson and Johnson, filed an opposition proceeding before the U.S. Patent &
Trademark Office's Trademark Trial & Appeal Board ("Trademark Board"), objecting
to one of the Company's applications to register the trademark ELEVESS, alleging
that the mark is confusingly similar to Colbar's previous mark EVOLENCE. The
only potential relief available in this proceeding is the denial of the
Company's trademark application; no damages or injunctive relief are possible.
In October 2008, Colbar filed a petition with the Trademark Board requesting
cancellation of the Company's second ELEVESS trademark that had been registered
in September 2008. The Company believes Colbar's claim and recent petition are
without merit, and has denied all substantive allegations in the notice of
opposition, and the parties are exploring settlement possibilities. As of June
30, 2009, the carrying value of the intangible asset related to ELEVESS was
$906,863 and the Company does not believe any impairment of the asset has
occurred. Please also refer to Note 3 under "Long-lived Assets" for more
discussions on the ELEVESS trade name intangible asset.



ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

     This Quarterly Report on Form 10-Q contains forward-looking statements
within the meaning of Section 27A of the Securities Act of 1933 and Section 21E
of the Securities Exchange Act of 1934, including statements regarding:

     o    our future sales and product revenues, including geographic
          expansions, possible retroactive price adjustments, and expectations
          of unit volumes or other offsets to price reductions;

     o    our manufacturing capacity and efficiency gains and work-in-process
          manufacturing operations;

     o    the timing, scope and rate of patient enrollment for clinical trials;

     o    development of possible new products;

     o    our ability to achieve or maintain compliance with laws and
          regulations;

     o    the timing of and/or receipt of the Food and Drug Administration
          ("FDA"), foreign or other regulatory approvals and/or reimbursement
          approvals of current, new or potential products, and any limitations
          on such approvals;

     o    negotiations with potential and existing partners, including our
          performance under any of our existing and future distribution or
          supply agreements or our expectations with respect to sales and sales
          threshold milestones pursuant to such agreements;

     o    the level of our revenue or sales in particular geographic areas
          and/or for particular products, and the market share for any of our
          products;

     o    our current strategy, including our corporate objectives and research
          and development and collaboration opportunities;

     o    our and Bausch & Lomb's performance under the existing supply
          agreement for certain of our ophthalmic viscoelastic products, our
          ability to remain the exclusive global supplier for AMVISC and AMVISC
          Plus to Bausch & Lomb, and our expectations regarding revenue from
          ophthalmic products;

     o    our ability, and the ability of our distribution partner, to market
          our aesthetic dermatology product;

     o    our expectations regarding our joint health products, including
          expectations regarding new products, expanded uses of existing
          projects, new distribution and revenue growth;

     o    our intention to increase market share for joint health products in
          international and domestic markets or otherwise penetrate growing
          markets for osteoarthritis of the knee and other joints;

     o    our expectations regarding next generation osteoarthritis/joint health
          product developments, clinical trials, regulatory approvals, and
          commercial launches;

     o    our expectations regarding HYVISC sales;

     o    our expectations regarding the development and commercialization of
          INCERT, and the market potential for INCERT;

     o    our expectations regarding the timing of the HYDRELLE product launch
          and related sales in the U.S.;

     o    our ability to license our aesthetics product to new distribution
          partners outside of the United States;

     o    our expectations regarding product gross margin;

     o    our expectations regarding next generation osteoarthritis/joint health
          product developments, clinical trials, regulatory approvals, and
          commercial launches;

     o    our expectations regarding the timing of our U.S. MONOVISC trials and
          related premarket approval ("PMA") filing with the FDA;


     o    our expectations regarding the commencement of our clinical trial for
          CINGAL and our ability to obtain regulatory approvals for CINGAL;

     o    our expectations regarding our existing aesthetics product's line
          extensions;

     o    our expectation for increases in operating expenses, including
          research and development and selling, general and administrative
          expenses;

     o    the rate at which we use cash, the amounts used and generated by
          operations, and our expectation regarding the adequacy of such cash;

     o    our expectation for capital expenditures spending and decline in
          interest income;

     o    possible negotiations or re-negotiations with existing or new
          distribution or collaboration partners;

     o    our expectations regarding our existing manufacturing facility and the
          new Bedford, MA facility, our expectations related to costs, including
          financing costs, to build-out and occupy the new facility, the timing
          of construction, and our ability to obtain FDA licensure for the
          facility;

     o    our abilities to comply with debt covenants;

     o    our ability to obtain additional funds through equity or debt
          financings, strategic alliances with corporate partners and other
          sources, to the extent our current sources of funds are insufficient;

     o    our plans to address the FDA's Warning Letter and Form 483 Notice of
          Observations and the impact any associated regulatory action would
          have on our business and operations; and

     o    our abilities to successfully defend our ELEVESS trademark.

         Furthermore, additional statements identified by words such as "will,"
"likely," "may," "believe," "expect," "anticipate," "intend," "seek,"
"designed," "develop," "would," "future," "can," "could," "outlook" and other
expressions that are predictions of or indicate future events and trends and
which do not relate to historical matters, also identify forward-looking
statements. You should not rely on forward looking statements because they
involve known and unknown risks, uncertainties and other factors, some of which
are beyond our control, including those factors described in the section titled
"Item 1A. Risk Factors" in the Company's Annual Report on Form 10-K for the year
ended December 31, 2008. These risks, uncertainties and other factors may cause
our actual results, performance or achievement to be materially different from
anticipated future results, performance or achievement, expressed or implied by
the forward-looking statements. These forward- looking statements are based upon
the current assumptions of our management and are only expectations of future
results. You should carefully review all of these factors, and you should be
aware that there may be other factors that could cause these differences,
including those factors discussed herein and in the "Management's Discussions
and Analysis of Financial Condition and Results of Operations" section of this
Quarterly Report on Form 10-Q, as well as the risk factors described in our
Annual Report on Form 10-K for the year ended December 31, 2008 and in our press
releases and other filings with the Securities and Exchange Commission. We
undertake no obligation to publicly update or revise any forward-looking
statement to reflect changes in underlying assumptions or factors of new
information, future events or other changes.

Management Overview

         Anika Therapeutics, Inc. ("Anika," the "Company," "we," "us," or "our")
was incorporated in 1992 as a Massachusetts company. Anika develops,
manufactures and commercializes therapeutic products for tissue protection,
healing and repair. These products are based on hyaluronic acid (HA), a
naturally occurring, biocompatible polymer found throughout the body. Due to its
unique biophysical and biochemical properties, HA plays an important role in a
number of physiological functions such as the protection and lubrication of soft
tissues and joints, the maintenance of the structural integrity of tissues, and
the transport of molecules to and within cells. Our currently manufactured and
marketed products consist of ORTHOVISC(R), which is an HA product used in the
treatment of some forms of osteoarthritis in humans; AMVISC(R), AMVISC(R) Plus,
STAARVISC(TM)-II, and ShellGel(TM), each an injectable ophthalmic viscoelastic
HA product. HYVISC(R), which is an HA product used in the treatment of equine
osteoarthritis, and INCERT(R), an HA based anti-adhesive for surgical
applications. ORTHOVISC(R) mini, a treatment for osteoarthritis targeting small
joints is available in Europe. MONOVISC(TM), a single-injection osteoarthritis
product based on our proprietary cross-linking technology is available in Europe
and Turkey. In the U.S. and several countries in Latin America, ORTHOVISC is
marketed by DePuy Mitek, Inc. ("DePuy Mitek"), a subsidiary of Johnson & Johnson
(collectively, "JNJ"), under the terms of a licensing, distribution, supply and
marketing agreement. Outside the U.S., ORTHOVISC has been approved for sale
since 1996 and is marketed by distributors in approximately 20 countries. We



developed and manufacture AMVISC(R) and AMVISC(R) Plus for Bausch & Lomb
Incorporated under a multiyear supply agreement. We also produce
STAARVISC(TM)-II, which is distributed by STAAR Surgical Company and
Shellgel(TM) for Cytosol Ophthalmics, Inc. HYVISC(R) is marketed in the U.S.
through Boehringer Ingelheim Vetmedica, Inc. INCERT(R) is currently marketed in
three countries outside of the U.S. Our aesthetic dermatology business is
designed to have a family of products for facial wrinkles and scar remediation.
Our initial aesthetic dermatology product is approved in the U.S., EU, Canada
and certain countries in South America. This product is marketed in the U.S. by
CoApt Systems, Inc. ("CoApt") under the name of HYDRELLE(TM). Internationally,
this product is marketed under the ELEVESS(TM) name. Products in development
include a next generation joint health related products and aesthetics product
line extension products.

Osteoarthritis Business

         Our joint health products include ORTHOVISC, ORTHOVISC mini, and
MONOVISC. ORTHOVISC is available in the U.S., Canada, and some international
markets for the treatment of osteoarthritis of the knee, and in Europe for the
treatment of osteoarthritis in all joints. ORTHOVISC mini is available in Europe
and is designed for the treatment of osteoarthritis in small joints. MONOVISC is
our single injection osteoarthritis treatment for all joints, and is available
in Europe and Turkey. ORTHOVISC mini, and MONOVISC are our two newest joint
health products and became available during the second quarter of 2008. Our
revenue from joint health products has increased 16.9% and 20.6% for the three
and six months ended June 30, 2009 compared with the same periods in 2008. This
increase is reflective of our continued focus in this therapeutic area, an area
with favorable demographics of an aging population looking to remain active. Our
strategy is to continue to add new products, to expand the indications for usage
of the products, and to add additional countries to our distribution network.
The joint health area has been the fastest growing area for the Company, growing
from 39% of our product revenue in 2005 to 62% of our product revenue for the
first six months of this year. We continue to seek new distribution partnerships
around the world and we expect total joint health product sales to increase in
2009 compared to 2008.

Ophthalmic Business

         Our ophthalmic business includes HA viscoelastic products used in
ophthalmic surgery. For the three and six months ended June 30, 2009, sales of
ophthalmic products contributed 28.3% and 29.6% of our product revenue,
respectively. Ophthalmic sales decreased by 3.2% and 8.1% for the three and six
month periods in 2009 compared to the same periods in 2008. The decrease in
sales for the three and six month periods was primarily due to order timing and
inventory management by our partners. Sales to Bausch & Lomb accounted for 96.0%
and 94.8% of ophthalmic sales for the three and six months ended June 30, 2009,
respectively, and contributed 27.2% and 28.1% of product revenue for the same
periods.

Veterinary Business

         Sales of HYVISC, our veterinary product for the treatment of equine
osteoarthritis, contributed 7.0% and 7.2% of our product revenue for the three
and six months ended June 30, 2009, respectively, and decreased by 40.1% and
27.4% compared to the same periods in 2008. The decrease for these periods was
primarily due to inventory management by our partner, Boehringer Ingelheim
Vetmedica. We expect HYVISC sales in 2009 to be flat with or lower than 2008.

Anti-adhesion Business

         INCERT, approved for sale in Europe and Turkey, is designed as a family
of HA based products, with chemically modified, cross-linked HA, for prevention
of post-surgical adhesions. We commenced INCERT sales during the second quarter
of 2006. INCERT is currently marketed in three countries. We see potential for
expanded indications for the use of INCERT, but have made this a secondary goal
to the successful launch and expanded distribution of our joint health and
aesthetic products. There are currently no plans at this time to distribute
INCERT in the U.S.

Aesthetic Dermatology Business

         Our aesthetic dermatology business is designed to have a family of
products for facial wrinkles and scar remediation, and is intended to compete
with collagen-based and other HA-based products currently on the market. Our
initial aesthetic dermatology product is a dermal filler based on our
proprietary chemically modified, cross-linked HA, and is approved in Europe,
Canada, the U.S. and certain countries in South America. This product is
marketed in the U.S. by CoApt under the name of HYDRELLE(TM). Our distribution
agreement with CoApt was signed in May 2009. We expect CoApt to begin selling
the product in the third quarter of 2009. Internationally the product is
marketed under the ELEVESS(TM) name. We continue to focus on the development and
expansion of the product in additional countries.



Research and Development

         Products in development include next generation joint health related
products. Our next generation osteoarthritis products include a single-injection
treatment product that uses a non-animal source HA, and is our first
osteoarthritis product based on our proprietary crosslinked HA-technology. This
product has been branded as MONOVISC. We received Conformite Europeene (CE) Mark
approval for the MONOVISC product in October 2007 and began sales in Europe
during the second quarter of 2008, following a small, post marketing clinical
study. In the U.S., we filed an Investigational Device Exemption, or an IDE
application, with the FDA, and completed patient enrollment for our U.S.
clinical trial in December of 2008. During the second quarter of 2009, we
completed the clinical segment of the U.S. MONOVISC pivotal trial. We expect to
complete the MONOVISC retreatment study in the U.S. and complete the PMA filing
with the FDA later in 2009. Our second single-injection osteoarthritis product
is CINGAL, which is based on the same technology platform used in MONOVISC, with
an added active therapeutic molecule to provide broad pain relief for a long
period of time. We expect to commence a clinical study and file an application
for CE Mark for CINGAL in 2009.

FDA Warning Letter

         In July 2008, we received a Warning Letter (the "Warning Letter") from
the FDA in response to an earlier FDA Form 483 Notice of Observations issued to
us following an inspection at our current manufacturing facility in Woburn,
Massachusetts. We have fully cooperated with the FDA to address the issues in
the Form 483 filing and have issued a response to the FDA's Warning Letter. We
have developed a corrective action plan and we have provided the FDA with
progress reports. On September 15, 2008, the FDA issued a letter to us
indicating that the responses submitted by us were sufficient. The FDA did
conduct a follow up inspection of the Company's Woburn facility and discussions
are ongoing to address all issues and clear the Warning Letter as rapidly as
possible. Product quality is the highest concern to us and we are committed to
the continual improvement of our quality systems. Failure to comply with
applicable regulatory requirements and to address the issues raised by the FDA
in the Warning Letter could result in regulatory action. Any such regulatory
action would be expected to have a material adverse effect on our business and
operations.

Summary of Critical Accounting Policies; Significant Judgments and Estimates

         Our discussion and analysis of our financial condition and results of
operations are based upon our financial statements, which have been prepared in
accordance with accounting principles generally accepted in the United States of
America. The preparation of these financial statements requires us to make
estimates and judgments that affect the reported amounts of assets, liabilities,
revenues and expenses, and related disclosure of contingent assets and
liabilities. We monitor our estimates on an on-going basis for changes in facts
and circumstances, and material changes in these estimates could occur in the
future. Changes in estimates are recorded in the period in which they become
known. We base our estimates on historical experience and other assumptions that
we believe to be reasonable under the circumstances. Actual results may differ
from our estimates if past experience or other assumptions do not turn out to be
substantially accurate.

         We have identified the policies below as critical to our business
operations and the understanding of our results of operations. The impact and
any associated risks related to these policies on our business operations is
discussed throughout "Management's Discussion and Analysis of Financial
Condition and Results of Operations" where such policies affect our reported and
expected financial results. For a detailed discussion on the application of
these and other accounting policies, see Note 3 to the Consolidated Financial
Statements of our Quarterly Reports on Form 10-Q for the three and six month
periods ended June 30, 2009 and 2008, respectively, and our Annual Report on
Form 10-K for the year ended December 31, 2008.

Revenue Recognition

         The Company's revenue recognition policies are in accordance with the
Securities and Exchange Commission's (SEC) Staff Accounting Bulletin No. 101,
"Revenue Recognition in Financial Statements," as amended by SEC Staff
Accounting Bulletin No. 104, "Revenue Recognition," and Emerging Issues Task
Force Issue No. 00-21, "Revenue Arrangements with Multiple Deliverables," and
EITF 07-1 "Accounting for Collaborative Arrangements," which became effective on
January 1, 2009. Adoption of EITF 07-1 did not impact our financial statements
for the three and six month periods ended June 30, 2009 and 2008.



Reserve for Obsolete/Excess Inventory

         Inventories are stated at the lower of cost or market. We regularly
review our inventories and record a provision for excess and obsolete inventory
based on certain factors that may impact the realizable value of our inventory
including, but not limited to, technological changes, market demand, inventory
cycle time, regulatory requirements and significant changes in our cost
structure. If ultimate usage varies significantly from expected usage or other
factors arise that are significantly different than those anticipated by
management, additional inventory write-down or increases in obsolescence
reserves may be required.

         We generally produce finished goods based upon specific orders or in
anticipation of specific orders. As a result, we generally do not establish
reserves against finished goods. We evaluate the value of inventory on a
quarterly basis and may, based on future changes in facts and circumstances,
determine that a write-down of inventory is required in future periods.

Stock-based Compensation

         The Company accounts for stock-based compensation under the provisions
SFAS No. 123R ("SFAS 123R"), "Share-Based Payment," which establishes accounting
for equity instruments exchanged for employee services. Under the provisions of
SFAS 123R, share-based compensation cost is measured at the grant date, based on
the calculated fair value of the award, and is recognized as an expense over the
employee's requisite service period (generally the vesting period of the equity
grant).

         The Company estimates the fair value of stock options and stock
appreciation rights using the Black-Scholes valuation model. Key input
assumptions used to estimate the fair value of stock options and stock
appreciation rights include the exercise price of the award, the expected award
term, the expected volatility of the Company's stock over the award's expected
term, the risk-free interest rate over the award's expected term, and the
Company's expected annual dividend yield. The Company uses historical data on
exercise of stock options and other factors to estimate the expected term of
share-based awards. The Company also evaluates forfeitures periodically and
adjusts accordingly. The expected volatility assumption is based on the
unadjusted historical volatility of the Company's common stock. The risk-free
interest rate assumption is based on U.S. Treasury interest rates at the time of
grants. Estimates of fair value are not intended to predict actual future events
or the value ultimately realized by persons who receive equity awards. For
awards with a performance condition vesting feature, when achievement of the
performance condition is deemed probable, the Company recognizes compensation
cost on a graded-vesting basis over the awards' expected vesting periods. The
Company assesses probability on a quarterly basis.

Income Taxes

         The Company accounts for uncertain income tax positions using a benefit
recognition model with a two-step approach, a more-likely-than-not recognition
criterion and a measurement attribute that measures the position as the largest
amount of tax benefit that is greater than 50% likely of being realized upon
ultimate settlement in accordance with FASB Interpretation No. 48, "Accounting
for Uncertainty in Income Taxes, an Interpretation of FASB Statement No. 109"
("FIN 48"). If it is not more likely than not that the benefit will be sustained
on its technical merits, no benefit will be recorded. Uncertain tax positions
that relate only to timing of when an item is included on a tax return are
considered to have met the recognition threshold. It is the Company's policy to
classify accrued interest and penalties as part of the accrued FIN 48 liability
and record the expense in the provision for income taxes.

         We record a deferred tax asset or liability based on the difference
between the financial statement and tax basis of assets and liabilities, as
measured by the enacted tax rates assumed to be in effect when these differences
reverse. As of June 30, 2009, management determined that it is more likely than
not that the deferred tax assets will be realized and, therefore, a valuation
allowance has not been recorded.

Asset Valuation

         Asset valuation includes assessing the recorded value of certain
assets, including accounts receivable, investments, inventories, and intangible
assets. We use a variety of factors to assess valuation, depending upon the
asset. Accounts receivable are evaluated based upon the credit-worthiness of our
customers, our historical experience, and the age of the receivable. The
determination of whether unrealized losses on investments are other than
temporary is based upon the type of investments held, market conditions, length
of the impairment, magnitude of the impairment and ability to hold the
investment to maturity. Should current market and economic conditions
deteriorate, our ability to recover the cost of our investments may be impaired.
The recoverability of inventories is based upon the types and levels of
inventory held and forecasted demand. Should current market and economic
conditions deteriorate, our actual recovery could be less than our estimate.
Intangible assets are evaluated based upon the expected period the asset will be
utilized, forecasted cash flows, and customer demand. Our intangible asset
consists of our ELEVESS trade name. During the second quarter of 2009, we signed
an exclusive distribution agreement with CoApt for the distribution in the
United States of Anika's aesthetic dermatology products for facial wrinkles.



CoApt is marketing this product under the name HYDRELLE(TM), which caused the
Company to perform a recoverability test in accordance with SFAS No. 144
requirements in order to determine if the carrying value for the ELEVESS trade
name was impaired. Our existing aesthetic dermatology product continues to be
marketed outside of the U.S. under the ELEVESS(TM) name. The analysis concluded
that the undiscounted cash flow exceeds the carrying value of the ELEVESS asset
group. Significant assumptions underlying the recoverability of the intangible
asset include: future cash flow, growth projections, product life cycle and
useful life assumptions. The ultimate recoverability of the asset is dependent
on us securing additional distributors. Recoverability of the carrying value of
the asset may also be impacted by the outcome of the pending trade name
opposition. Changes in these assumptions could materially impact the Company's
ability to realize the value of its intangible asset.

         On January 1, 2009, the Company adopted FSP No. 142-3, "Determination
of the Useful Life of Intangible Assets" ("FSP 142-3"). This FSP amends the
factors that should be considered in developing renewal or extension assumptions
used to determine the useful life of a recognized intangible asset under SFAS
No. 142, "Goodwill and Other Intangible Assets." The adoption did not have an
impact on our financial position and results of operations for the three and six
month periods ended June 30, 2009.

Property and Equipment

         Property and equipment are carried at cost less accumulated
depreciation, subject to review for impairment whenever events or changes in
circumstances indicate that the carrying amount of the asset may not be
recoverable. Costs of major additions and improvements are capitalized;
maintenance and repairs that do not improve or extend the life of the respective
assets are charged to operations. On disposal, the related accumulated
depreciation or amortization is removed from the accounts and any resulting gain
or loss is included in results of operations. Depreciation is computed using the
straight-line method over the estimated useful lives of the assets. Leasehold
improvements are amortized over the lesser of the useful life or the expected
term of the respective lease. Machinery and equipment are depreciated from 5 to
10 years, furniture and fixtures from 5 to 7 years and computer software and
hardware from 3 to 5 years. Interest costs incurred during the construction of
major capital projects are capitalized in accordance with SFAS No. 34,
"Capitalization of Interest Costs" ("SFAS 34"). The interest is capitalized
until the underlying asset is ready for its intended use, at which point the
interest cost is amortized as interest expense over the life of the underlying
assets. We capitalize certain direct and incremental costs associated with the
validation effort related to FDA approval of our manufacturing facility and
equipment for the production of our commercial products. These costs include
construction costs, equipment costs, direct labor and materials incurred in
preparing the facility and equipment for their intended use. The validation
costs are amortized over the life of the related facility and equipment.

Results of Operations

Three and six months ended June 30, 2009 compared to three and six months ended
June 30, 2008.

Product Revenue

         Product revenue for the quarter ended June 30, 2009 was $8,770,763, an
increase of $391,827 or 4.7%, compared to $8,378,936 for the quarter ended June
30, 2008. Product revenue for the six months ended June 30, 2009 was
$17,289,836, an increase of $1,043,371 or 6.4%, compared to $16,246,465 for the
six months ended June 30, 2008.


                          Three Months Ended June 30,             Increase (Decrease)
                       ----------------------------------  ----------------------------------
                             2009              2008                $                 %
                       ----------------  ----------------  ----------------  ----------------
                                                                 
Joint Health           $     5,568,685   $     4,765,474    $      803,211             16.9%
Ophthalmic                   2,480,923         2,562,218           (81,295)            -3.2%
Veterinary                     611,600         1,020,394          (408,794)           -40.1%
Aesthetics                      88,080            13,050            75,030                NM
Other                           21,475            17,800             3,675                NM
                       ----------------  ----------------  ----------------
                       $     8,770,763   $     8,378,936   $       391,827              4.7%
                       ================  ================  ================

NM - Not meaningful






                          Six Months Ended June 30,               Increase (Decrease)
                       ----------------------------------  ----------------------------------
                             2009              2008                $                 %
                       ----------------  ----------------  ----------------  ----------------
                                                                 
Joint Health           $    10,718,327   $     8,887,654   $     1,830,673             20.6%
Ophthalmic                   5,126,175         5,580,889          (454,714)            -8.1%
Veterinary                   1,248,935         1,721,017          (472,082)           -27.4%
Aesthetics                     138,174            16,050           122,124                NM
Other                           58,225            40,855            17,370                NM
                       ----------------  ----------------  ----------------
                       $    17,289,836   $    16,246,465   $     1,043,371              6.4%
                       ================  ================  ================

NM - Not meaningful


         Our joint health products consist of ORTHOVISC, ORTHOVISC mini and
MONOVISC, the latter two of which are currently only available outside the
United States. Revenue from joint health products increased $803,211, or 16.9%,
in the second quarter of 2009 from the second quarter of 2008. For the six
months ended June 30, 2009, joint health product sales increased $1,830,673, or
20.6% compared with the same period in 2008. The improvement in joint health
product revenue for the three and six months ended June 30, 2009 was primarily
due to increases in domestic ORTHOVISC and international MONOVISC revenue. Our
U.S. joint health product revenue in the second quarter of 2009 totaled
$4,096,281, compared to $3,193,897 in the same period last year, an increase of
28.3%. Our U.S. joint health product revenue for the six months ended June 30,
2009 totaled $7,759,483, compared to $6,480,770 in the same period last year, an
increase of 19.7%. The increase reflects DePuy Mitek's underlying sales
increases to end-users of 32.6% and 31.8% for the three and six months ended
June 30, 2009 compared to the same periods in 2008, reflecting their increased
marketing efforts. International joint health product revenue in the second
quarter of 2009 decreased 6.3% to $1,472,404, from $1,571,577 in the second
quarter last year. International joint health product revenue in the six months
ended June 30, 2009 increased 22.9% to $2,958,844, from $2,406,884 in the same
period last year. The decrease in international revenue in the second quarter of
2009 was primarily due to decreased product shipments to Turkey and Italy. The
increase in international revenue during the six months ended June 30, 2009 was
due to increased product shipments to France, Turkey, Egypt, and Hungary. We
expect joint health product revenue to increase in 2009 compared to 2008, both
domestically and internationally.

         Our sales of ophthalmic products decreased $81,295, or 3.2%, and
$454,714, or 8.1% for the three and six months ended June 30, 2009,
respectively, as compared with the same periods last year. The change in
ophthalmic product sales for the three and six months period was primarily
related to order timing and inventory management by our partners.

         Sales of HYVISC, our veterinary product, decreased 40.1% and 27.4% for
the three and six months ended June 30, 2009 compared with the same periods last
year. The decrease for the period was primarily due to inventory management by
our partner, Boehringer Ingelheim Vetmedica. We expect HYVISC revenue in 2009 to
be flat with or lower than in 2008.

         Sales of our aesthetics product increased $75,030 and $122,124 for the
three and six months ended June 30, 2009 as compared to the same periods last
year. ELEVESS revenue for both periods was primarily a result of our limited
direct marketing efforts in the United States. During the second quarter of
2009, the Company signed an exclusive distribution agreement with CoApt for the
distribution of our aesthetic dermatology products in the U.S. under the name
HYDRELLE(TM). In key markets outside of the U.S., we continue to seek marketing
and distribution partners to commercialize ELEVESS.

         Licensing, milestone and contract revenue. Licensing, milestone and
contract revenue for the quarter ended June 30, 2009 was $752,913 compared to
$681,253 for the same period last year. For the six month period ended June 30,
2009, licensing, milestone and contract revenue was $1,434,164 compared to
$1,362,503 for the same period last year. The increase was due to a new product
development contract with an existing distributor. Licensing and milestone
revenue includes the ratable recognition of $27,000,000 in up-front and
milestone payments related to the JNJ agreement. These amounts are being
recognized in income ratably over the ten-year expected life of the agreement,
or $675,000 per quarter through the fourth quarter of 2013.

         Product gross profit. Product gross profit for the three and six month
periods ended June 30, 2009 were $5,476,603 and $10,784,010, respectively, or
62.4% of product revenue. Product gross profit for the three and six month
periods ended June 30, 2008 were $4,734,406 and $9,385,865, or 56.5% and 57.8%
of product revenue, respectively. The increases in product gross profit dollars



for the three and six month periods in 2009 were primarily due to higher product
sales and more favorable product mix compared to the same periods in 2008.

         Research & development. Research and development expenses for the
quarter ended June 30, 2009 was $2,286,229, an increase of $641,610, or 39.0%,
compared to $1,644,619 for the quarter ended June 30, 2008. For the six months
ended June 30, 2009, research and development expenses were $4,480,537, an
increase of $1,327,578, or 42.1%, compared to $3,152,959 for the same period in
2008. The increases in research and development expenses for the three and six
month periods were primarily related to our U.S.-based clinical trials for
MONOVISC, U.S.-based post-approval clinical trial for our aesthetics product,
and manufacturing validation activities at our Bedford facility, as well as
other continuing new product development projects. We expect research and
development expenses will continue to increase but at a slower rate in the
future related to next generation joint health products, our aesthetics product
line extension products, and other research and development programs in the
pipeline.

         Selling, general & administrative. Selling, general and administrative
expenses for the quarter ended June 30, 2009 was $2,735,552, a decrease of
$144,604, or 5.0%, compared to $2,880,156 for the quarter ended June 30, 2008.
For the six months ended June 30, 2009, selling, general and administrative
expenses were $5,770,534, a decrease of $178,238, or 3.0% compared to $5,948,772
for the same period in 2008. The decreases in the three and six month periods
were primarily the result of lower personnel related costs and marketing
expenses, which more than offset the increase in operating expenses related to
the new manufacturing facility in Bedford. Prior year's spending also included
marketing expenses related to MONOVISC and ORTHOVISC mini launches. We expect
that general and administrative expenses in 2009 to be higher than 2008.

         Interest income (expense), net. Net interest expense for the three
months ended June 30, 2009 was $1,382 compared to a net interest income of
$157,875 for the same period last year. For the six months ended June 30, 2009,
net interest income was $58, a decrease of $347,281 from the same period last
year. The decrease was primarily attributable to lower interest rates as a
result of the current rate environment. The net expense for the three months
ended June 30, 2009 represents interest expense related to our facilities' asset
retirement obligations.

         Income taxes. Provisions for income taxes were $250,579 and $235,830
for the three months ended June 30, 2009 and 2008, respectively. Provisions for
income taxes were $488,667 and $563,431 for the six months ended June 30, 2009
and 2008, respectively. The effective tax rates for the six months ended June
30, 2009 and 2008 were 24.8% and 28.3%, respectively. The decrease in effective
tax rate was primarily due to an increase in research credits in 2009. During
the six months ended June 30, 2009, there was no change to the Company's FIN 48
tax reserves. Our U.S. federal income tax returns for the years 2005, 2006, and
2007 remain subject to examination, and our state income tax returns for the
years 2006 and 2007 remain subject to examination.

Liquidity and Capital Resources

         We require cash to fund our operating expenses and capital
expenditures. We expect that our requirement for cash to fund these uses will
increase as the scope of our operations expands. Prior to 2008, we funded our
cash requirements from available cash and investments on hand. In 2008, we
borrowed from a line of credit with Bank of America to partially fund our
Bedford, Massachusetts facility capital project. At June 30, 2009, cash and cash
equivalents totaled $39,549,558 compared to $43,193,655 at December 31, 2008.

         Cash used in operating activities was $285,618 for the six months ended
June 30, 2009 compared with cash provided by operating activities of $881,619
for the six months ended June 30, 2008. This change was primarily due to
increases in inventory and accounts receivable partially offset by the timing of
payments to vendors.

         Cash used in investing activities was $2,565,804 for the six months
ended June 30, 2009, compared to $8,106,719 for the six months ended June 30,
2008. During the first six months in 2009, cash used in investing activities was
due to approximately $2.6 million in capital expenditures related to our new
facility. During the first six months in 2008, cash used in investing activities
was due to approximately $11.6 million in capital expenditures related to our
new facility, partially offset by the maturity in February 2008 of a short-term
tax exempt municipal bond of $3,500,000, which was purchased in February of
2007. We expect our capital expenditures in 2009 to decrease compared to 2008 as
the new facility capital project winds down. The new facility capital project
cost is approximately $32 million (including interior construction, equipment,
furniture and fixtures). At June 30, 2009, there was approximately $2 million of
remaining costs to be spent during the remainder of 2009. Construction commenced
in May 2007 and validation of the facility is expected to be completed in late
2009. We expect to occupy our existing manufacturing facility through the first
quarter of 2010 and begin some manufacturing at the Bedford, Massachusetts
facility in late 2009. There can also be no assurance that we will be successful
in qualifying the new facility under FDA and European Union regulations.



         Cash used in financing activities was $792,675 for the first six months
in 2009, which was due to our principal payments on the long-term debt in the
amount of $800,000. This was partially offset by small amounts from employee
stock exercise proceeds and related tax benefits. Cash provided by financing
activities was $8,619,010 for the first six months ended June 30, 2008 as a
result of the $8,000,000 borrowed under the Company's unsecured credit facility,
and proceeds of $476,811 from employee stock option exercises, and a tax benefit
from the exercise of stock options of $229,920. This was partially offset by
debt issuance costs of $87,721.

Recent Accounting Pronouncements

         On January 1, 2009, we adopted the following new accounting
pronouncements:

         FASB EITF Issue No. 07-1 ("EITF 07-1"), "Accounting for Collaborative
Arrangements". EITF 07-1 defines collaborative arrangements and establishes
reporting requirements for transactions between participants in a collaborative
arrangement and between participants in the arrangement and third parties. EITF
07-1 requires collaborators to present the results of activities for which they
act as the principal on a gross basis and report any payments received from
(made to) other collaborators based on other applicable GAAP or, in the absence
of other applicable GAAP, based on analogous authoritative accounting
literature, or a reasonable, rational, and consistently applied accounting
policy election. Further, EITF 07-1 clarifies that the determination of whether
transactions within a collaborative arrangement are part of a vendor-customer
(or analogous) relationship subject to EITF 01-9. EITF 07-1 was applied
retrospectively to all prior periods presented for all collaborative
arrangements existing as of the effective date. Adoption of EITF 07-1 did not
impact our financial statements for the three and six month periods ended June
30, 2009 and 2008.

         FASB Staff Position EITF Issue 03-6-1, "Determining Whether Instruments
Granted in Share-Based Payment Transactions Are Participating Securities"
clarifies that share-based payment awards that entitle their holders to receive
non-forfeitable dividends before vesting should be considered participating
securities. As participating securities, these instruments are included in the
calculation of basic earnings per share. FSP EITF 03-6-1 is effective for the
Company in 2009. The adoption of EITF Issue 03-6-1 did not have a material
impact on the Company's earnings per share calculations.

         FASB SFAS No. 141(R), "Business Combinations", revised SFAS No. 141,
"Business Combinations." The statement retains the purchase method of accounting
for acquisitions, but requires a number of changes, including changes in the way
assets and liabilities are recognized in the purchase accounting. It also
changes the recognition of assets acquired and liabilities assumed arising from
contingencies, requires the capitalization of in-process research and
development at fair value, and requires the expensing of acquisition-related
costs as incurred. The adoption did not have a material impact on our financial
statements.

         FASB Staff Position No. 142-3, "Determination of the Useful Life of
Intangible Assets" amends the factors that should be considered in developing
renewal or extension assumptions used to determine the useful life of a
recognized intangible asset under SFAS No. 142, "Goodwill and Other Intangible
Assets". The intent of this FSP is to improve the consistency between the useful
life of a recognized intangible asset under SFAS No. 142 and the period of
expected cash flows used to measure the fair value of the asset under SFAS No.
141(R), "Business Combinations," and other U.S. generally accepted accounting
principles. The adoption of this pronouncement did not impact our financial
statements in the three and six months ended June 30, 2009.

         On June 3, 2009, the FASB approved the FASB Accounting Standards
Codification, or the Codification, as the single source of authoritative
nongovernmental Generally Accepted Accounting Principles, or GAAP, in the United
States. The Codification will be effective for interim and annual periods ending
after September 15, 2009. Upon the effective date, the Codification will be the
single source of authoritative accounting principles to be applied by all
nongovernmental U.S. entities. All other accounting literature not included in
the Codification will be nonauthoritative. We do not expect the adoption of the
Codification to have an impact on our financial position or results of
operations.

         Effective this quarter, we implemented Statement of Financial
Accounting Standards No. 165, Subsequent Events, or SFAS 165. This standard
establishes general standards of accounting for and disclosure of events that
occur after the balance sheet date but before financial statements are issued.
The adoption of SFAS 165 did not impact our financial position or results of
operations. We evaluated all events or transactions that occurred through August
5, 2009, the date we issued these financial statements. During this period we
did not have any material recognizable subsequent events.

         Effective this quarter, the Company also implemented FSP FAS 107-1 and
APB 28-1, "Interim Disclosures about Fair Value of Financial Instruments" ("FSP
FAS 107-1"). FSP FAS 107-1 amended SFAS No. 107, Disclosures about Fair Value of
Financial Instruments, and APB Opinion No. 28, Interim Financial Reporting, to



require disclosures about the fair value of financial instruments in interim as
well as in annual financial statements. The adoption of this standard has
resulted in the disclosure of the fair value of the Company's long term debt
instrument on a quarterly basis. Since FSP FAS 107-1 addresses disclosure
requirements, the adoption of this FSP did not impact our financial position or
results of operations. The carrying value of our debt instrument was $15,200,000
at June 30, 2009. The estimated fair value of our debt instrument was
approximately $14,400,000 at June 30, 2009. The fair value was estimated using
market observable inputs and interest rate measurements.


Contractual Obligations and Other Commercial Commitments

         We expect to incur significant capital investments related to the
build-out and validation of our new facility in Bedford, Massachusetts. This
capital project is being financed with cash on hand and debt. On January 31,
2008, we entered into an unsecured credit agreement with Bank of America (the
"Credit Agreement"). Under the Credit Agreement we were provided with a
revolving credit line through December 31, 2008 of up to a maximum principal
amount at any time outstanding of $16,000,000. We borrowed the maximum amount of
$16,000,000 in 2008 to finance our new facility construction and validation
capital project. On December 31, 2008, the outstanding revolving credit loans
were converted into a term loan, in accordance with the terms of the Credit
Agreement, with quarterly principal payments of $400,000 and a final installment
of $5,200,000 due on the maturity date of December 31, 2015. Long-term debt
principal payments over the next five years are $1,600,000 per year. We
commenced making quarterly principal payments in 2009. Total debt outstanding
was $15,200,000 as of June 30, 2009. Construction of this new facility commenced
in May 2007 and validation is expected to be completed in 2009. To the extent
that funds generated from our operations, together with our existing capital
resources, are insufficient to meet future requirements, we will be required to
obtain additional funds through equity or debt financings, strategic alliances
with corporate partners and others, or through other sources. No assurance can
be given that any additional financing will be made available to us or will be
available on acceptable terms should such a need arise.

ITEM 3.     QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

         There have been no material changes to our market risks since the date
of our Annual Report on Form 10-K for the year ended December 31, 2008.

         As of June 30, 2009, we did not utilize any derivative financial
instruments, market risk sensitive instruments or other financial and commodity
instruments for which fair value disclosure would be required under SFAS No. 107
and SFAS No. 161. Our investments consist of money market funds primarily
invested in U.S. Treasury obligations and repurchase agreements secured by U.S.
Treasury obligations, and municipal bonds that are carried on our books at
amortized cost, which approximates fair market value.

Primary Market Risk Exposures

         Our primary market risk exposures are in the areas of interest rate
risk and currency rate risk. We have two supplier contracts denominated in
foreign currencies. Unfavorable fluctuations in exchange rates would have a
negative impact on our financial statements. The impact of changes in currency
exchange rates for the two contracts on our financial statements were immaterial
during the first six months of 2009. Our investment portfolio of cash
equivalents and long-term debt are subject to interest rate fluctuations. As of
June 30, 2009, we were subject to interest rate risk on $15.2 million of
variable rate debt. The interest payable on our debt is determined based on
either an interest rate based on LIBOR plus 0.75% or the lender's prime rate
and, therefore, is affected by changes in market interest rates. Based on the
outstanding debt amount as of June 30, 2009, we would have a decrease in future
annual cash flows of approximately $145,000 for every 1% increase in the
interest rate over the next twelve month period.

ITEM 4.     CONTROLS AND PROCEDURES

         (a) Evaluation of disclosure controls and procedures.

         As required by Rule 13a-15 under the Securities Exchange Act of 1934,
         as amended, ("Exchange Act"), we carried out an evaluation under the
         supervision and with the participation of our management, including our
         chief executive officer and chief financial officer, of the
         effectiveness of the design and operation of our disclosure controls
         and procedures as of the end of the period covered by this report.
         Based upon that evaluation, the chief executive officer and principal
         financial officer have concluded that our disclosure controls and
         procedures are effective to ensure that information required to be
         disclosed by us in reports we file or submit under the Exchange Act is


         recorded, processed, summarized and reported, within the time periods
         specified in Securities and Exchange Commission rules and forms.
         Disclosure controls and procedures include, without limitation,
         controls and procedures designed to ensure that information required to
         be disclosed by the Company in the reports it files or submits under
         the Exchange Act is accumulated and communicated to the Company's
         management, including our chief executive officer and chief financial
         officer, as appropriate to allow timely decisions regarding required
         disclosure. On an on-going basis, we review and document our disclosure
         controls and procedures, and our internal control over financial
         reporting, and may from time to time make changes aimed at enhancing
         their effectiveness and to ensure that our systems evolve with our
         business.

         (b) Changes in internal controls over financial reporting.

         There were no changes in our internal control over financial reporting
         during the second quarter of fiscal year 2009 that have materially
         affected, or that are reasonably likely to materially affect, our
         internal controls over financial reporting.



PART II: OTHER INFORMATION

Item 1.     LEGAL PROCEEDINGS

         On December 12, 2007, Colbar Lifescience Ltd. ("Colbar"), a subsidiary
of Johnson & Johnson, filed an opposition proceeding before the U.S. Patent &
Trademark Office's Trademark Trial & Appeal Board ("Trademark Board"), objecting
to one of the Company's applications to register the trademark ELEVESS, alleging
that the mark is confusingly similar to Colbar's previous mark EVOLENCE. The
only potential relief available in this proceeding is the denial of the
Company's trademark application; no damages or injunctive relief are possible.
In October 2008, Colbar filed a petition with the Trademark Board requesting
cancellation of the Company's second ELEVESS trademark that had been registered
in September 2008. The Company believes Colbar's claim and recent petition are
without merit, and has denied all substantive allegations in the notice of
opposition, and the parties are exploring settlement possibilities. As of June
30, 2009, the carrying value of the intangible asset related to ELEVESS was
$906,863. The Company does not believe any impairment of the asset has occurred.

Item 1A.    RISK FACTORS

         There have been no material changes in the risk factors described in
"Item 1A. Risk Factors" in our Annual Report on Form 10-K for the year ended
December 31, 2008, except to the extent additional factual information disclosed
elsewhere in this Quarterly Report on Form 10-Q relates to such risk factors. In
addition to the other information set forth in this report, you should carefully
consider the factors discussed in Part I, "Item 1A. Risk Factors" in our Annual
Report on Form 10-K for the year ended December 31, 2008, which could materially
affect our business, financial condition or future results. The risks described
in our Annual Report on Form 10-K are not the only risks facing our Company.
Additional risks and uncertainties not currently known to us or that we
currently deem to be immaterial also may materially adversely affect our
business, financial condition and/or operating results.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

         The Company's Annual Meeting of Stockholders was held on June 5, 2009.
The proposals before our stockholders and the results of voting on such
proposals were as noted below.

(1)      The stockholders of the Company elected Drs. Joseph L. Bower and Eugene
         A. Davidson to serve on the Board of Directors as Class I directors
         until the Annual Meeting of Stockholders to be held in 2012 and until
         their respective successors are duly elected and qualified. The
         tabulation of votes with respect to the election of such directors is
         as follows:

             -------------------------------------------------------------------
                                                    Number of Shares
             -------------------------------------------------------------------
                                           Votes For             Votes Withheld
             -------------------------------------------------------------------
             Joseph L. Bower               6,220,864               4,372,979
             -------------------------------------------------------------------
             Eugene A. Davidson            7,704,344               2,889,499
             -------------------------------------------------------------------

         Following the meeting, the Company's Board of Directors consists of
Charles H. Sherwood, Joseph L. Bower (Lead Director), Eugene A. Davidson,
Raymond J. Land, John C. Moran and Steven E. Wheeler.

(2)      The stockholders of the Company approved the Company's Amended and
         Restated 2003 Stock Option and Incentive Plan (the "Plan"). The
         tabulation of votes with respect to the approval of the Plan is as
         follows:

             -------------------------------------------------------------------
                                      Number of Shares
             -------------------------------------------------------------------
                    Votes For           Votes Against         Votes Abstained
             -------------------------------------------------------------------
                    5,172,603             1,304,421               18,249
             -------------------------------------------------------------------



ITEM 6. EXHIBITS

Exhibit No.                           Description
-------------  -----------------------------------------------------------------

(10)           Material Contracts

10.1           Letter Agreement, dated April 27, 2009, by and between the
               Company and Frank J. Luppino, incorporated herein by reference to
               Exhibit 10.1 to the Company's Current Report on Form 8-K (File
               no. 001-14027), filed with the Securities and Exchange Commission
               on May 29, 2009.

10.2           Anika Therapeutics, Inc. Amended and Restated 2003 Stock Option
               and Incentive Plan, incorporated herein by reference to Exhibit
               10.1 to the Company's Current Report on Form 8-K (File no.
               001-14027), filed with the Securities and Exchange Commission on
               June 11, 2009.

(11)           Statement Regarding Computation of Per Share Earnings

*11.1          See Note 6 to the Financial Statements included herewith.

(31)           Rule 13a-14(a)/15d-14(a) Certifications

*31.1          Certification of Charles H. Sherwood, Ph.D. pursuant to Rules
               13a-15(e) and 15d-15(e), as adopted pursuant to Section 302 of
               the Sarbanes-Oxley Act of 2002.

*31.2          Certification of Kevin W. Quinlan pursuant to Rules 13a-15(e) and
               15d-15(e), as adopted pursuant to Section 302 of the
               Sarbanes-Oxley Act of 2002.

(32)           Section 1350 Certifications

**32.1         Certification of Charles H. Sherwood, Ph.D. and Kevin W. Quinlan,
               pursuant to 18 U.S.C. Section 1350, as adopted pursuant to
               Section 906 of the Sarbanes-Oxley Act of 2002.

---------------------------
*        Filed herewith.

**       Furnished herewith.



                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                                  ANIKA THERAPEUTICS, INC.

August 5, 2009                               By:  /s/ KEVIN W. QUINLAN
                                                  ------------------------------
                                                  Kevin W. Quinlan
                                                  Chief Financial Officer
                                                  (Principal Financial Officer)