SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                          (Amendment No.___________)*


                      Interneuron Pharmaceuticals, Inc.
              -----------------------------------------------------
                                (Name of Issuer)

                      Common Stock, $.001 par value
          -------------------------------------------------------------
                         (Title of Class of Securities)

                                460573108
              -----------------------------------------------------
                                 (CUSIP Number)

                              December 28, 2000
              ----------------------------------------------------
                             (Date of Event)




Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[  ] Rule 13d-1(b)

[XX] Rule 13d-1(c)

[  ] Rule 13d-1(d)




*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




                                Page 1 of 6 pages



CUSIP No. 460573108           13G                    Page 2 of 6 Pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Dov Perlysky


--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY




--------------------------------------------------------------------------------
   4   CITIZENSHIP OR PLACE OF ORGANIZATION


       United States

--------------------------------------------------------------------------------
   NUMBER OF      5    SOLE VOTING POWER
     SHARES            2,548,481
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      6    SHARED VOTING POWER
      EACH             74,000
   REPORTING      --------------------------------------------------------------
     PERSON       7    SOLE DISPOSITIVE POWER
      WITH             2,548,481
                  --------------------------------------------------------------
                  8    SHARED DISPOSITIVE POWER
                       74,000
--------------------------------------------------------------------------------
   9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                      2,622,481
--------------------------------------------------------------------------------
  10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*



--------------------------------------------------------------------------------
  11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


                       6.1%

-------------------------------------------------------------------------------
  12   TYPE OF REPORTING PERSON*


                      IN

--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT



CUSIP No. 460573108           13G                    Page 3 of 6 Pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Laya Perlysky


--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY




--------------------------------------------------------------------------------
   4   CITIZENSHIP OR PLACE OF ORGANIZATION


       United States

--------------------------------------------------------------------------------
   NUMBER OF      5    SOLE VOTING POWER
     SHARES            2,548,481
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      6    SHARED VOTING POWER
      EACH             74,000
   REPORTING      --------------------------------------------------------------
     PERSON       7    SOLE DISPOSITIVE POWER
      WITH             2,548,481
                  --------------------------------------------------------------
                  8    SHARED DISPOSITIVE POWER
                       74,000
--------------------------------------------------------------------------------
   9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


                      2,622,481
--------------------------------------------------------------------------------
  10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*



--------------------------------------------------------------------------------
  11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


                       6.1%

-------------------------------------------------------------------------------
  12   TYPE OF REPORTING PERSON*


                      IN

--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT






                                                          Page 3 of 5 Pages


Item 1.     (a)   Name of Issuer:

                  Interneuron Pharmaceuticals, Inc.

            (b)   Address of Issuer's Principal Executive Offices:

                  One Ledgemont Center
                  99 Hayden Avenue
                  Lexington, MA  02421

Item 2.     (a)   Name of Person Filing:

               This  statement is filed on behalf of Dov  Perlysky  ("Dov")
               and Laya Perlysky ("Laya") (together,  the "Reporting  Parties").
               See  attached  Exhibit  A which is a copy of their  agreement  in
               writing to file this statement on behalf of each of them.

            (b)   Address of Principal Business Office:

                    The Reporting parties address is 9 Beechwood Drive,
                    Lawrence, NY  11559


            (c)   Citizenship:

                    Both are citizens of the United States.

            (d)   Title of Class of Securities:

                    Common Stock, $.001 par value ("shares")

            (e)   CUSIP Number:

                    460573108


Item 3.     If this statement  is filed  pursuant to Rules  13d-1(b), or
            13d-2(b), check whether the person filing is a:

            (a)   [ ]   Broker or Dealer  registered under Section  15 of  the
                        Act

            (b)   [ ]   Bank as defined in section 3(a)(6) of the Act

            (c)   [ ]   Insurance Company  as defined  in section  3(a)(19) of
                        the Act

            (d)   [ ]   Investment Company registered under  section 8 of  the
                        Investment Company Act of 1940

            (e)   [ ]   An investment adviser in accordance with 240.13d-1
                        (b)(1)(ii)(E)

            (f)   [ ]   An employee benefit Plan or endowment fund in
                        accordance with 240.13d-1(b)(1)(ii)(F)

            (g)   [ ]   A parent holding Company or control person in
                        accordance  with  240.13d-1(b)(1)(ii)(G)

            (h)   [ ]   A savings associations as defined in Section 3(b) of
                        the Federal Deposit Insurance Act

            (i)   [ ]   A church plan that is excluded from definition of an
                        investment company under section 3(c)(14) of the
                        Investment Company Act of 1940.





                                                             Page 4 of 5 Pages

Item 4.     Ownership.

      (a)  (b) The Reporting  Parties may each be deemed to beneficially own
               2,622,481  shares or 6.1% of the Issuer's shares as follows:  (i)
               1,890,000  shares  owned  directly by Dov  Perlysky,  (ii) 74,000
               shares owned by a charitable  entity  controlled by the Reporting
               Parties, and (iii) 658,481 shares owned directly by Laya Perlysky
               (1).


          (c)  Dov has sole voting and  dispositive  control of shares  owned by
               him.  Laya  Perlysky  has sole voting and  dispositve  power over
               shares  owned   directly  by  her.   Both  have  the  voting  and
               dispositive control over shares owned by the charitable entity.

Item 5.     Ownership of Five Percent or Less of a Class.

            Not applicable.


Item 6.     Ownership of More Than Five Percent on Behalf of Another Person.

            Not applicable.


Item 7.     Identification and Classification of the Subsidiary which Acquired
            the Security Being Reported on By the Parent Holding Company.

            Not applicable.

Item 8.     Identification and Classification of Members of the Group.

            Not applicable.

Item 9.     Notice of Dissolution of Group.

            Not applicable.

Item 10.    Certification.

               By  signing  below, I  certify  that,  to the  best  of my
               knowledge and belief,  the securities  referred to above were not
               acquired  and are not held for the  purpose of or with the effect
               of  changing  or  influencing  the  control  of the issuer of the
               securities  and were not acquired and are not held in  connection
               with or as a participant in any  transaction  having that purpose
               or effect.


                                   Signature.

 After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information  set forth in this statement is true, complete and correct.




Dated:    December 28, 2000              /s/ Dov Perlysky
          Lawrence, New York            ______________________________
                                        Dov Perlysky





Dated:    December 28, 2000              /s/ Laya Perlysky
          Lawrence, New York            ______________________________
                                        Laya Perlysky

___________________________________________________________________________
 (1) Dov and Laya Perlysky are husband and wife.  Filing of this statement
shall not be deemed an admission by Dov Perlysky or Laya Perlysky that they
beneficially own the securities attributed to the other for any purpose.  They
expressly disclaim beneficial ownership of all securities held by each other.